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    Glossary Dedifferentiation

    process where mature cells revert to a primitive state

    Dedifferentiation is a biological process where specialized, mature cells revert to a more primitive, unspecialized state. This can occur in response to injury or stress and is significant in regenerative medicine and cancer research, as it can lead to tissue repair or, conversely, uncontrolled cell growth.

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    Research 30 of 1000+

    1. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    2. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    3. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice Journal of Clinical Investigation · 2019 · 136 citations
    4. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations
    5. Differentiation of the sebaceous gland Dermato-Endocrinology · 2009 · 60 citations
    6. Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens Differentiation · 2012 · 51 citations
    7. Hair follicle differentiation‐specific keratin expression in human basal cell carcinoma Clinical and Experimental Dermatology · 2019 · 45 citations
    8. Eph/ephrin signaling in epidermal differentiation and disease Seminars in Cell & Developmental Biology · 2011 · 42 citations
    9. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    10. Dissection of a Complex Enhancer Element: Maintenance of Keratinocyte Specificity but Loss of Differentiation Specificity Molecular and Cellular Biology · 2002 · 42 citations
    11. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    12. Proliferation and Differentiation of Cultured Human Keratinocytes is Modulated by 1,25(OH)<sub>2</sub>D<sub>3</sub> and Synthetic Vitamin D<sub>3</sub> Analogues in a Cell Density‐, Calcium‐ and Serum‐Dependent Manner* Pharmacology & toxicology · 1997 · 39 citations
    13. The cDNA-deduced amino acid sequence for trichohyalin, a differentiation marker in the hair follicle, contains a 23 amino acid repeat. 1990 · 39 citations
    14. Desmoglein 4 is regulated by transcription factors implicated in hair shaft differentiation Differentiation · 2009 · 35 citations
    15. Biphasic Effects of Minoxidil on the Proliferation and Differentiation of Normal Human Keratinocytes Skin Pharmacology and Physiology · 2009 · 34 citations
    16. Structural features and sites of expression of a new murine 65 kD and 48 kD hair-related keratin pair, associated with a special type of parakeratotic epithelial differentiation Differentiation · 1992 · 28 citations
    17. Foxn1 promotes keratinocyte differentiation by regulating the activity of protein kinase C Differentiation · 2007 · 26 citations
    18. Characterization of a gene encoding a cysteine-rich keratin associated protein synthesized late in rabbit hair follicle differentiation Differentiation · 1995 · 26 citations
    19. Differentiation of human hair follicle stem cells into endothelial cells induced by vascular endothelial and basic fibroblast growth factors Molecular Medicine Reports · 2013 · 24 citations
    20. Planar cell polarity effector gene Intu regulates cell fate-specific differentiation of keratinocytes through the primary cilia Cell death and differentiation · 2012 · 19 citations
    21. Differentiation of Human Pluripotent Stem Cells Into Definitive Endoderm Cells in Various Flexible Three-Dimensional Cell Culture Systems: Possibilities and Limitations Frontiers in Cell and Developmental Biology · 2021 · 13 citations
    22. miR‐203a‐3p promotes loureirin A‐induced hair follicle stem cells differentiation by targeting Smad1 ˜The œanatomical record · 2020 · 12 citations
    23. Effect of X-Irradiation on Differentiating Hair Follicles The anatomical record · 1960 · 12 citations
    24. Differentiation of the basal cell epithelioma-like changes overlying dermatofibroma. Acta Dermato Venereologica · 1991 · 12 citations
    25. Clonal analysis of stem cells in differentiation and disease Current Opinion in Cell Biology · 2016 · 11 citations
    26. In vitro Differentiation of Hair Follicle Stem Cell into Keratinocyte by Simvastatin Iranian Biomedical Journal · 2019 · 10 citations
    27. Differentiation of Human Dermal Mesenchymal Stem Cells into Cardiomyocytes by Treatment with 5-Azacytidine: Concept for Regenerative Therapy in Myocardial Infarction ISRN Stem Cells (Online) · 2013 · 9 citations
    28. Differentiation and Apoptosis in Pilomatrixoma American Journal of Dermatopathology · 2011 · 9 citations
    29. Human melanocyte development and melanoma dedifferentiation at single cell resolution bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 9 citations
    30. Apoptosis coordinates with proliferation and differentiation during human hair follicle morphogenesis Journal of dermatological science · 2005 · 7 citations