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    Glossary Dedifferentiation

    process where mature cells revert to a primitive state

    Dedifferentiation is a biological process where specialized, mature cells revert to a more primitive, unspecialized state. This can occur in response to injury or stress and is significant in regenerative medicine and cancer research, as it can lead to tissue repair or, conversely, uncontrolled cell growth.

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    1. Dedifferentiation of committed epithelial cells into stem cells in vivo Nature · 2013 · 551 citations
    2. Wounding induces dedifferentiation of epidermal Gata6+ cells and acquisition of stem cell properties Nature cell biology · 2017 · 143 citations
    3. Dermal adipose tissue has high plasticity and undergoes reversible dedifferentiation in mice Journal of Clinical Investigation · 2019 · 136 citations
    4. Two Opposing Faces of Retinoic Acid: Induction of Stemness or Induction of Differentiation Depending on Cell-Type Biomolecules · 2019 · 41 citations
    5. Clonal analysis of stem cells in differentiation and disease Current Opinion in Cell Biology · 2016 · 11 citations
    6. Human melanocyte development and melanoma dedifferentiation at single cell resolution bioRxiv (Cold Spring Harbor Laboratory) · 2020 · 9 citations
    7. Differentiation of Human Pluripotent Stem Cells Into Definitive Endoderm Cells in Various Flexible Three-Dimensional Cell Culture Systems: Possibilities and Limitations Frontiers in Cell and Developmental Biology · 2021 · 13 citations
    8. Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage 2010 · 101 citations
    9. Differentiation of the sebaceous gland Dermato-Endocrinology · 2009 · 60 citations
    10. Specific morphogenetic events in mouse external genitalia sex differentiation are responsive/dependent upon androgens and/or estrogens Differentiation · 2012 · 51 citations
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