Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice

    September 2019 in “ Journal of Clinical Investigation ”
    Zhuzhen Zhang, Mengle Shao, Chelsea Hepler … Philipp E. Scherer
    Studysummary This study found that mature dermal adipocytes have high plasticity, undergoing dedifferentiation and redifferentiation, which plays a significant role in hair cycling and wound healing.
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    Research cited in this study 13

    1. The Role of Immature and Mature Adipocytes in Hair Cycling Trends in Endocrinology and Metabolism · 2018
    2. Skin Aging as a Mechanical Phenomenon: The Main Weak Links Nutrition and healthy aging · 2018
    3. Emerging Nonmetabolic Functions of Skin Fat Nature Reviews Endocrinology · 2018
    4. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    5. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis Cell Stem Cell · 2016
    6. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    7. Dermal White Adipose Tissue: A New Component of the Thermogenic Response Journal of Lipid Research · 2015
    8. Defining Dermal Adipose Tissue Experimental Dermatology · 2014
    9. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    10. Adipocytes in Skin Health and Disease Cold Spring Harbor Perspectives in Medicine · 2014
    11. Lipoatrophy and Severe Metabolic Disturbance in Mice with Fat-Specific Deletion of PPARγ Proceedings of the National Academy of Sciences of the United States of America · 2013
    12. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    13. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011