Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice

The study demonstrated that dermal adipose tissue (dWAT) in mice exhibited high plasticity, undergoing reversible dedifferentiation into fibroblast-like and adipocyte progenitor-like cells, which could then redifferentiate back into mature adipocytes. This plasticity was crucial for hair follicle cycling, wound healing, and skin homeostasis. The findings suggested that dWAT played a significant role in skin health and could be a potential target for therapeutic strategies in conditions like alopecia and fibrosis. The research was supported by various experiments, including single-cell RNA sequencing and in vivo proliferation assays, involving multiple groups of mice.