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    Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis

    October 2016 in “ Cell Stem Cell ”
    Guillermo C. Rivera-Gonzalez, Brett A. Shook, Johanna Andræ … Valerie Horsley
    Studysummary This study found that PDGFA is critical for the proliferation and maintenance of adipocyte stem cells in skin but not other white adipose tissues, highlighting unique regulatory mechanisms in different tissue depots.
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    Research cited in this study 12

    1. Dermal White Adipose Tissue: A New Component of the Thermogenic Response Journal of Lipid Research · 2015
    2. Stem Cell Heterogeneity and Plasticity in Epithelia Cell Stem Cell · 2015
    3. Somatic Stem Cell Heterogeneity: Diversity in the Blood, Skin, and Intestinal Stem Cell Compartments Nature Reviews Molecular Cell Biology · 2015
    4. Pioneer Factors Govern Super-Enhancer Dynamics in Stem Cell Plasticity and Lineage Choice Nature · 2015
    5. Hair Follicle Dermal Stem Cells Regenerate the Dermal Sheath, Repopulate the Dermal Papilla, and Modulate Hair Type Developmental Cell · 2014
    6. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014
    7. Calcineurin/NFATc1 Signaling Links Skin Stem Cell Quiescence to Hormonal Signaling During Pregnancy and Lactation Genes & Development · 2014
    8. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    9. Distinct Fibroblast Lineages Determine Dermal Architecture in Skin Development and Repair Nature · 2013
    10. Dermal Papilla Cell Number Specifies Hair Size, Shape, and Cycling, and Its Reduction Causes Follicular Decline Development · 2013
    11. Live Imaging of Stem Cell and Progeny Behavior in Physiological Hair-Follicle Regeneration Nature · 2012
    12. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011