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GlossaryPlatelet-Derived Growth Factor AA (PDGFA)

stimulates cell growth and tissue repair, including hair follicles

Platelet-Derived Growth Factor AA (PDGF-AA) is a protein that plays a crucial role in cell growth, healing, and development. It is one of the isoforms of PDGF, which are important for stimulating the proliferation and differentiation of cells, particularly in the context of wound healing and tissue repair. In the realm of hair biology, PDGF-AA can influence hair follicle development and regeneration, making it a potential target for treatments related to hair loss and alopecia.

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research Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis

106 citations, October 2016 in “Cell Stem Cell”

PDGFA/AKT signaling is important for the growth and maintenance of certain skin fat cells.

research PDGFA Regulation of Dermal Adipocyte Stem Cells

3 citations, September 2017 in “Stem cell investigation”

PDGF signaling is crucial for maintaining fat stem cells in the skin, and its level of activation can either preserve these cells or cause fibrosis.

research Influence of Melatonin Implanting on PDGFA Gene Expression in Skin Hair Follicle

January 2012

Melatonin shortens the hair growth cycle by increasing PDGFA gene expression.

research Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling

499 citations, September 2011 in “Cell”

Fat-related cells are important for initiating hair growth.

research Multi-Layered Environmental Regulation on the Homeostasis of Stem Cells: The Saga of Hair Growth and Alopecia

59 citations, February 2012 in “Journal of Dermatological Science”

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.

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community Seriously confused about minoxidil's method of action

in Minoxidil 6 upvotes 2 years ago

The conversation discusses confusion about how Minoxidil promotes hair growth compared to other substances like Menthol, which have similar actions. The user mentions personal positive results with peppermint oil extract and is currently trying L-citrulline for its vasodilation effects.

community 2 years later I managed to gain some ground (Hyperresponder)

in Progress Pictures 43 upvotes 1 year ago

The user regained most of their hair using Minoxidil, Finasteride, and Dermarolling. They found Dermarolling particularly effective, as it promotes growth factors and improves hair thickness.

community Surprisingly thorough study on He-Shou-Wu/Fo Ti

in Research/Science 14 upvotes 1 year ago

He Shou Wu (Fo Ti) extract was found to prolong the hair growth phase, inhibit 5-alpha-reductase (like finasteride), reduce androgen receptors, and increase growth factors, potentially outperforming minoxidil in recovering hair follicle size after DHT exposure. Two compounds, emodin and TSG, are identified as responsible for these effects and warrant further investigation.

community Comprehensive Microneedling Guide

in Microneedling 295 upvotes 2 years ago

Microneedling for hair restoration involves daily use of a 0.3 mm device and weekly use of a 0.5 mm device. Combining microneedling with Minoxidil can enhance hair growth.