TLDR Syndecan-1 is essential for maintaining skin fat and preventing cold stress.
The study concluded that Syndecan-1 (Sdc1) was crucial for maintaining intradermal fat, which played a significant role in thermoregulation and protecting against cold stress in mice. Mice lacking Sdc1 exhibited reduced intradermal fat, leading to increased heat loss, chronic cold stress, and systemic metabolic changes. The absence of Sdc1 impaired adipocyte differentiation and lipid accumulation, which could be partially rescued by the PPARγ agonist rosiglitazone. These findings underscored the importance of Sdc1 in skin physiology, fat metabolism, and thermal regulation.
499 citations,
September 2011 in “Cell” Fat-related cells are important for initiating hair growth.
41 citations,
June 2010 in “Journal of Investigative Dermatology” New cells are added to the hair's dermal papilla during the active growth phase.
42 citations,
May 2016 in “Annual Review of Cell and Developmental Biology” Fat cells are important for tissue repair and stem cell support in various body parts.
92 citations,
September 2015 in “Journal of Lipid Research” Skin fat helps with body temperature control and has other active roles in health.
65 citations,
January 2018 in “Nature Reviews Endocrinology” Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.
49 citations,
March 2019 in “Journal of Investigative Dermatology” Skin fat plays a key role in immune defense and healing beyond just storing energy.
69 citations,
December 2016 in “Facial plastic surgery” Different types of facial fat affect aging and treatment outcomes; more research is needed to enhance anti-aging procedures.
