Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress

The study concluded that Syndecan-1 (Sdc1) was crucial for maintaining intradermal fat, which played a significant role in thermoregulation and protecting against cold stress in mice. Mice lacking Sdc1 exhibited reduced intradermal fat, leading to increased heat loss, chronic cold stress, and systemic metabolic changes. The absence of Sdc1 impaired adipocyte differentiation and lipid accumulation, which could be partially rescued by the PPARγ agonist rosiglitazone. These findings underscored the importance of Sdc1 in skin physiology, fat metabolism, and thermal regulation.