The Role of Immature and Mature Adipocytes in Hair Cycling

    December 2018 in “ Trends in Endocrinology and Metabolism ”
    Ilja L. Kruglikov, Zhuzhen Zhang, Philipp E. Scherer
    Studysummary The authors concluded that dermal white adipose tissue, influenced by factors like light irradiation, plays a significant role in modulating hair follicle cycles and could be targeted for hair growth treatments.
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    Research cited in this study 17

    1. Identifying Novel Strategies for Treating Human Hair Loss Disorders: Cyclosporine A Suppresses the Wnt Inhibitor, SFRP1, in the Dermal Papilla of Human Scalp Hair Follicles PLOS Biology · 2018
    2. Emerging Nonmetabolic Functions of Skin Fat Nature Reviews Endocrinology · 2018
    3. Adipocyte-Myofibroblast Transition as a Possible Pathophysiological Step in Androgenetic Alopecia Experimental Dermatology · 2017
    4. Regeneration of Fat Cells from Myofibroblasts During Wound Healing Science · 2017
    5. Skin Adipocyte Stem Cell Self-Renewal Is Regulated by a PDGFA/AKT Signaling Axis Cell Stem Cell · 2016
    6. Hair Follicles’ Transit-Amplifying Cells Govern Concurrent Dermal Adipocyte Production Through Sonic Hedgehog Genes & Development · 2016
    7. Skin Aging: Are Adipocytes the Next Target? Aging · 2016
    8. The Role of Adipocytes in Tissue Regeneration and Stem Cell Niches Annual Review of Cell and Developmental Biology · 2016
    9. Hair Regeneration Using Adipose-Derived Stem Cells PubMed · 2016
    10. Re-Evaluating Cyclosporine A as a Hair Growth–Promoting Agent in Human Scalp Hair Follicles Journal of Investigative Dermatology · 2015
    11. MicroRNA-214 Controls Skin and Hair Follicle Development by Modulating the Activity of the Wnt Pathway Journal of Cell Biology · 2014
    12. Epidermal Wnt/β-Catenin Signaling Regulates Adipocyte Differentiation via Secretion of Adipogenic Factors Proceedings of the National Academy of Sciences of the United States of America · 2014
    13. A Review of Adipocyte Lineage Cells and Dermal Papilla Cells in Hair Follicle Regeneration Journal of Tissue Engineering · 2014
    14. Melanin Light Absorption as the Necessary but Not Sufficient Condition for Photoepilation: Miniaturization and Eclipse Phenomena The American Journal of Cosmetic Surgery · 2013
    15. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    16. Hair Growth Promoting Effects of Adipose Tissue-Derived Stem Cells Journal of Dermatological Science · 2009
    17. PDGF Isoforms Induce and Maintain Anagen Phase of Murine Hair Follicles Journal of Dermatological Science · 2006