Skin Aging: Are Adipocytes the Next Target?

    July 2016 in “ Aging ”
    Ilja L. Kruglikov, Philipp E. Scherer
    Studysummary This study suggests that dermal adipocytes might play a key role in skin aging due to their transformation into fibrotic structures in chronically photo-damaged skin.
    Automatically generated from the study's abstract, not written by a person, and not a review of the full paper. Not medical advice or a treatment recommendation. Read the original study, and consult a qualified healthcare professional before changing treatment. Full disclaimer
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    Research cited in this study 13

    1. Dermal White Adipose Tissue: A New Component of the Thermogenic Response Journal of Lipid Research · 2015
    2. The Modulatable Stem Cell Niche: Tissue Interactions During Hair and Feather Follicle Regeneration Journal of Molecular Biology · 2015
    3. Syndecan-1 Is Required to Maintain Intradermal Fat and Prevent Cold Stress PLOS genetics · 2014
    4. Defining Dermal Adipose Tissue Experimental Dermatology · 2014
    5. Intradermal Adipocytes Mediate Fibroblast Recruitment During Skin Wound Healing Development · 2013
    6. Ultraviolet B Preconditioning Enhances the Hair Growth-Promoting Effects of Adipose-Derived Stem Cells Via Generation of Reactive Oxygen Species Stem Cells and Development · 2012
    7. Gender Differences in Skin Aging and the Changing Profile of the Sex Hormones with Age Journal of Steroids & Hormonal Science · 2012
    8. Adipocyte Lineage Cells Contribute to the Skin Stem Cell Niche to Drive Hair Cycling Cell · 2011
    9. Nfatc1 Balances Quiescence and Proliferation of Skin Stem Cells Cell · 2008
    10. Gender Differences in Mouse Skin Morphology and Specific Effects of Sex Steroids and Dehydroepiandrosterone Journal of Investigative Dermatology · 2005
    11. Targeted Overexpression of the Angiogenesis Inhibitor Thrombospondin-1 in the Epidermis of Transgenic Mice Prevents Ultraviolet-B-Induced Angiogenesis and Cutaneous Photo-Damage Journal of Investigative Dermatology · 2002
    12. Metabolic And Cellular Analysis Of Alopecia In Vitamin D Receptor Knockout Mice Journal of Clinical Investigation · 2001
    13. Towards Defining the Pathogenesis of the Hairless Phenotype Journal of Investigative Dermatology · 1998