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Glossary Hypertrophic Scars

raised, thickened skin areas from excessive collagen after injury

Hypertrophic scars are raised, thickened areas of skin that form at the site of an injury or incision. Unlike keloid scars, which can grow beyond the boundaries of the original wound, hypertrophic scars remain confined to the wound area but can be red, itchy, and sometimes painful. They result from an overproduction of collagen during the healing process and can improve over time, though treatments like silicone sheets, corticosteroid injections, or laser therapy may be used to reduce their appearance.

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research Combination of lyophilized adipose-derived stem cell concentrated conditioned medium and polysaccharide hydrogel in the inhibition of hypertrophic scarring

45 citations , January 2021 in “Stem Cell Research & Therapy”

This study found that incorporating adipose-derived stem cell conditioned medium into a polysaccharide hydrogel effectively reduced scar hyperplasia, with the combination offering better outcomes in preventing hypertrophic scarring compared to the medium alone in a rabbit ear model.

research Mesenchymal Stem Cells From Mouse Hair Follicles Reduce Hypertrophic Scarring in a Murine Wound Healing Model

13 citations , January 2022 in “Stem cell reviews and reports”

This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.

research The Secretome of Irradiated Peripheral Mononuclear Cells Attenuates Hypertrophic Skin Scarring

1 citations , March 2023 in “Pharmaceutics”

This study found that PBMCsec has anti-fibrotic effects on mouse and human skin scars by regulating pro-fibrotic gene expression and inhibiting myofibroblast differentiation and elastic fiber breakdown.

research Gut microbiota-derived metabolites in keloid and hypertrophic scarring

3 citations , September 2025 in “Frontiers in Microbiology”

This review article proposes a possible skin-gut-fibrosis axis, suggesting that gut microbial metabolites may influence the development of keloids and hypertrophic scars by affecting immune responses and fibrotic signaling pathways, although direct evidence in skin fibrosis remains limited.

research Toward understanding scarless skin wound healing and pathological scarring

113 citations , June 2019 in “F1000Research”

This review discusses the mechanisms of wound healing and excessive scarring, highlighting the importance of understanding these processes for developing new therapies to prevent fibrotic scarring in large skin wounds.

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community DHT Harms Scalp Microbiome: DHT Itch is REAL

413 upvotes 1 year ago

Increased Malassezia and Cutibacterium in the scalp microbiome are linked to higher sebum production and inflammation in androgenetic alopecia (AGA). Treatments include ciclopirox shampoo, benzoyl peroxide shampoo, clobetasol propionate, calcipotriol, minoxidil, finasteride, and dutasteride.

community What's "wrong" with oral minoxidil, exactly?

in Minoxidil 173 upvotes 1 year ago

Oral minoxidil can boost hair growth but may cause side effects like heart palpitations and increased body hair. Many prefer topical minoxidil due to fewer side effects.

community How does dutasteride regrowth work?

in Finasteride/Dutasteride 7 upvotes 2 years ago

A 25-year-old man with hair loss from bleach damage is using oral minoxidil and considering adding Dutasteride for better regrowth and prevention. He seeks advice on Dutasteride's effectiveness and potential benefits over finasteride, and is also curious about RU58841.

community How is there still no consensus on Topical Dutasteride in 2024?

in Finasteride/Dutasteride 147 upvotes 2 years ago

The conversation expresses frustration over the lack of clear evidence regarding the effectiveness and systemic impact of topical Dutasteride for hair loss treatment, despite years of discussion. People are criticized for not conducting proper research and for providing contradictory anecdotal claims.

community Temporalis Hypertrophy and hair loss

in Treatment 24 upvotes 1 year ago

Hair loss treatments include finasteride, minoxidil, and scalp exercises. Opinions vary on the effectiveness, with some attributing hair loss to muscle tension and inflammation, while others focus on genetics and DHT.

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