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GlossaryDermal White Adipose Tissue (DWAT)

layer of fat in the skin's dermis aiding hair growth

Dermal White Adipose Tissue (DWAT) is a layer of fat located within the skin, specifically in the dermis. It plays a crucial role in skin homeostasis, providing insulation, energy storage, and contributing to the skin's structural integrity. DWAT is also involved in hair follicle cycling and wound healing, making it an important area of study for both dermatology and metabolic research.

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research Adipocyte-Myofibroblast Transition as a Possible Pathophysiological Step in Androgenetic Alopecia

18 citations, May 2017 in “Experimental Dermatology”

AMT may cause hair loss and changing dWAT activity could help treat it.

research Defining Dermal Adipose Tissue

218 citations, May 2014 in “Experimental Dermatology”

Skin fat cells help with skin balance, hair growth, and healing wounds.

research Dermal Adipose Tissue Has High Plasticity And Undergoes Reversible Dedifferentiation In Mice

136 citations, September 2019 in “Journal of Clinical Investigation”

Dermal adipose tissue in mice can change and revert to help with skin health.

research Dermal Fibroblasts in Cutaneous Development and Healing

115 citations, December 2017 in “Wiley Interdisciplinary Reviews-Developmental Biology”

Skin cells called dermal fibroblasts are important for skin growth, hair growth, and wound healing.

research Dermal White Adipose Tissue: A New Component of the Thermogenic Response

92 citations, September 2015 in “Journal of Lipid Research”

Skin fat helps with body temperature control and has other active roles in health.

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community The Big Fat Layer II

in Research/Science 26 upvotes 3 years ago

Hair loss treatment should target dermal white adipose tissue (DWAT) to restore hair follicles. Potential remedies include tocopherol (vitamin E), botox, rosiglitazone, niacin, kojyl cinnamate esters, and ADP355.

community The Big Fat Layer / Remedies: Cetirizine

in Treatment 12 upvotes 3 years ago

Treating hair loss with various remedies, such as Cetirizine and the Big3 complex (minoxidil, finasteride, and RU58841), which have properties like adipogenic, anti-fibrotic and anti-inflammatory. References to research studies are also included.