Skin Aging as a Mechanical Phenomenon: The Main Weak Links

    May 2018 in “ Nutrition and healthy aging ”
    Ilja L. Kruglikov, Philipp E. Scherer
    Image of study
    TLDR Skin aging is largely due to differences in stiffness and elasticity between skin layers, leading to wrinkles.
    The document from 2018 examines skin aging from a mechanical perspective, emphasizing the importance of the mechanical properties and interactions between different skin layers. It identifies that the mismatch in stiffness, adhesive strength, and thickness ratios between layers such as the stratum corneum, epidermis, dermis, and subcutaneous white adipose tissue (sWAT) contributes to the formation of wrinkles. The study suggests that a reduction in elastic fibers during aging decreases the skin's resistance to wrinkling and that anti-aging strategies should focus on reducing the mechanical mismatch between layers rather than just reinforcing the dermis. The paper also notes that changes in the sWAT layer, including its collagen network, can affect skin mechanics, and that understanding these mechanical properties is key to developing effective anti-aging treatments. The document does not involve a clinical trial or a specific number of participants, as it is a mechanical analysis rather than a study on people.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community I am actually regrowing my hairline without minoxidil or finasteride (mechanical stimulation)

       128 upvotes 6 years ago
      Regrowing hairline without the use of Minoxidil or Finasteride, and instead using mechanical stimulation such as Derma Roller, Nizoral, Zinc Pyrithione, Scalp Massage, Scalp Exercise, Fish Oil and other topical solutions. It is cautioned that there are risks associated with not using medically-prescribed treatments, but it is suggested to consider mechanical stimulation in addition to those prescribed treatments.

      community Anyone here going the “natural” route?

      in Scalp Massage  48 upvotes 2 years ago
      People discussing their experiences with natural treatments for hair loss, such as essential oils, deep scalp massages, anti-inflammatory measures, and supplements. Most of the replies suggest that these treatments are not effective and recommend medication such as minoxidil or finasteride instead.

      community Exploring Bryan Johnson's Hair Routine In Detail

      in Research/Science  64 upvotes 11 months ago
      Bryan Johnson uses a custom hair loss treatment that includes topical finasteride, minoxidil, azelaic acid, diclofenac, tea tree oil, rosemary oil, ginkgo biloba, biotin, and melatonin, which have shown varying degrees of effectiveness with minimal side effects. He also undergoes PRP and laser therapy, and has tried dutasteride mesotherapy.

      community Opinions on Scalp fibrosis and DHT?

      in Research/Science  9 upvotes 2 years ago
      The conversation discusses the theory that scalp fibrosis contributes to male pattern baldness (MPB) by increasing DHT concentration, and mentions treatments like Minoxidil. The user seeks opinions on the theory and the effectiveness of scalp massages.

    Related Research

    1 / 1 results