Adipocytes in Skin Health and Disease

    March 2014 in “ Cold Spring Harbor Perspectives in Medicine ”
    Guillermo C. Rivera-Gonzalez, Brett A. Shook, Valerie Horsley
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    TLDR Fat cells are important for healthy skin, hair growth, and healing, and changes in these cells can affect skin conditions and aging.
    The document from March 1, 2014, examines the role of adipocytes in skin health and their involvement in hair follicle growth, wound healing, and skin diseases. It explains that adipocytes in the dermal layer change in size during the hair cycle and communicate with hair follicles. The formation of dermal adipocytes is postnatal and linked to hair follicle formation, with their development being controlled by the maturation of precursor cells that proliferate in sync with the hair cycle. The inhibition of the adipogenic transcription factor PPARY can block adipocyte growth during the hair cycle and wound healing. The review also discusses the impact of hormonal changes on skin homeostasis and the potential decline in adipogenesis contributing to age-related hair loss. Furthermore, it highlights the need for future research on the role of adipocyte precursor cells in skin aging and wound healing, as well as the influence of sex hormones on dermal adipocytes. The document also emphasizes the importance of fatty acids and adipokines from adipocytes for skin function and suggests that lipid metabolism and adipocyte-secreted molecules could be key in understanding skin-related disorders in obesity.
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