Aging of Hair

    Ralph M. Trüeb
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    TLDR Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.
    The 2005 document examines the process of hair aging, which includes changes to the hair shaft and follicle, leading to graying and decreased hair production in conditions like androgenetic alopecia (AGA) and senescent alopecia. It identifies both intrinsic factors, such as genetics, and extrinsic factors, like UV radiation and smoking, as contributors to hair aging, with oxidative stress playing a significant role. The paper discusses treatments for AGA, including topical minoxidil, oral finasteride, and hair transplantation, as well as the use of hair colorants for graying. It notes that AGA affects a significant portion of the population, with at least 50% of men by age 50 and up to 70% later in life, and 6% of women under 50, increasing to 30-40% at age 70. The document also explores the negative effects of smoking and UV radiation on hair health and emphasizes the importance of public awareness. Additionally, it reviews hair care recommendations for aging hair, such as frequent shampooing, shorter hairstyles, and intensive conditioning treatments, and highlights ongoing research into new hair care formulas and potential "anti-aging" compounds for hair and scalp care.
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      community Looks like a real cure to the root of baldness (DHT-induced senescence) was proven earlier this year

      in Research/Science  734 upvotes 2 years ago
      A study that outlines the full model for androgenic alopecia (AGA) which links DHT to cellular senescence in dermal papilla cells, and suggests black chokeberry as a source of cyanidin 3-O-arabinoside polyphenol with potential anti-oxidant properties that could reverse this process. The post encourages reaching out to experts in anti-aging and longevity to research treatments involving the polyphenol.

      community The mechanism of androgenic alopecia

      in Research/Science  32 upvotes 5 days ago
      DHT may inhibit hair growth by affecting mitochondrial function, leading to hair follicle miniaturization. Treatments like minoxidil and PP405 may promote hair growth by altering metabolic pathways, potentially counteracting DHT's effects.

      community If PP405 goes systemic this would be quite catastrophic

      in Research/Science  5 upvotes 8 months ago
      Concerns about the potential systemic effects and safety of PP405 for hair loss, with discussions on its comparison to existing treatments like finasteride and minoxidil. Users express skepticism about untested research chemicals and emphasize the importance of clinical trials to ensure safety and efficacy.

      community New Hair Loss Treatment: Adipose Derived Secretomes

      in Research/Science  18 upvotes 5 months ago
      Adipose-derived stem cell secretome showed significant improvement in hair density and growth, especially when combined with minoxidil, suggesting a synergistic effect. The study had limitations, including a small sample size and potential bias.

      community Why do we get bald from evolutionary perspective

      in Chat  213 upvotes 3 months ago
      Baldness is not an evolutionary disadvantage because it occurs after reproductive age. Treatments like Minoxidil and Finasteride are used for androgenetic alopecia but don't address the root cause.

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