Improvement in the Inflammatory Aspect of Androgenetic Alopecia: A Pilot Study with an Antimicrobial Lotion

January 1996 in “ Journal of Dermatological Treatment ”

Gérald Pierard, Claudine Piérard-Franchimont, Nazli Nikkels-Tassoudji, Arjen Nikkels, D. Saint Leger

androgenetic alopecia antimicrobial lotion piroctone olamine triclosan hair density inflammation microorganisms infrainfundibulum AGA

Studysummary This study found that using an antimicrobial lotion for 18 months may reduce inflammation and potentially partially reverse hair loss in men with androgenetic alopecia.

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A pilot study with varying sample sizes found that applying an antimicrobial lotion containing piroctone olamine and triclosan twice daily for 3-18 months significantly reduced inflammation and increased hair density in individuals with androgenetic alopecia. The lotion was well-tolerated with no adverse effects reported, suggesting that it may be a promising treatment option for AGA. However, larger studies are needed to confirm these findings. The study suggests that controlling microorganisms in the infrainfundibulum could potentially prevent and partially reverse hair loss in AGA.

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Research cited in this study

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Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

research Expression of the L-Fucose Moiety on Infrainfundibular Follicular Keratinocytes of Terminal Follicles, Its Decreased Expression on Vellus and Indeterminate Follicles of Androgenetic Alopecia, and Re-Expression in Drug-Induced Hair Regrowth

9 citations , January 1992 in “Journal of Investigative Dermatology”

This study found distinct differences in UEA I glycoprotein binding on follicular keratinocytes between anagen and telogen hair follicles, with staining associated with follicle length and regrowth.

research Cutaneous Immunopathology of Androgenetic Alopecia

13 citations , August 1991 in “The Journal of the American Osteopathic Association”

This research found evidence of inflammatory involvement in androgenetic alopecia, with higher deposition of certain immune components in the scalp of affected patients compared to those without baldness.

research Natural Progression of Male Pattern Baldness in Young Men

71 citations , May 1991 in “Clinical and Experimental Dermatology”

Young men with male pattern baldness lose hair density over time without treatment.

research Natural History of Androgenetic Alopecia

7 citations , January 1990 in “Clinical and Experimental Dermatology”

This study observed that without any treatment, hair counts did not increase, suggesting that counting methods are unlikely to explain the 'placebo-effect' seen in previous minoxidil studies.

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-Pattern Baldness

51 citations , January 1989 in “Journal of Investigative Dermatology”

This study found that sebaceous glands in bald scalp have greater androgen binding affinity and capacity than those in hairy scalp, possibly contributing to the androgenic response seen in male pattern baldness.

research The Comparative Histopathology of Male-Pattern Baldness and Senescent Baldness

143 citations , October 1988 in “Clinics in Dermatology”

This review discusses the histopathology of male-pattern baldness and highlights ongoing disputes over several aspects, including sebaceous gland size and follicle loss, reporting no new clinical findings.

research Etiology and Diagnosis of Androgenetic Alopecia

9 citations , October 1988 in “Clinics in Dermatology”

This paper discusses androgenetic alopecia, its causes, synonyms, and patterns, but reports no new findings or clinical results.

research Safety and Efficacy of Topical Minoxidil in the Management of Androgenetic Alopecia

67 citations , March 1987 in “Journal of The American Academy of Dermatology”

This study found that both 2% and 3% minoxidil resulted in a significant increase in hair counts for participants with androgenetic alopecia over 12 months.

research Dose-Response Study of Topical Minoxidil in Male Pattern Baldness

58 citations , July 1986 in “Journal of The American Academy of Dermatology”

Lowest effective minoxidil concentration is 1%, but 2% works better for male pattern baldness.

research Topical Minoxidil in Early Male Pattern Baldness

138 citations , August 1985 in “Journal of The American Academy of Dermatology”

Minoxidil promotes hair growth in male pattern baldness.

research Male Pattern Alopecia: A Histopathologic and Histochemical Study

94 citations , August 1975 in “Journal of Cutaneous Pathology”

In this study, the researchers observed that male pattern alopecia is characterized by miniature follicles, enlarged sebaceous glands, and an increased number of mast cells, without significant abnormalities in enzyme activity.