The Inflammatory Aspect of Male and Female Pattern Hair Loss

November 2020 in “ Journal of Inflammation Research ”

Nadia Peyravian, Sapna K. Deo, Sylvia Daunert, Joaquin J. Jimenez

male pattern hair loss female pattern hair loss inflammation anti-inflammatory treatments chronic inflammation perivascular infiltration mast cells MPHL FPHL

TLDR Inflammation affects hair loss; anti-inflammatory treatments may help.

This article discusses the role of inflammation in male and female pattern hair loss and the potential for anti-inflammatory treatments to improve hair growth. Studies have found chronic inflammation in tissue specimens of MPHL and FPHL patients, with perivascular infiltration of mast cells suggesting a relationship between inflammation and MPHL. Targeting inflammation may be a potential therapeutic approach for MPHL and FPHL.

View this study on dovepress.com →

Discuss this study in the Community →

Cited in this study

15 / 15 results

research A Review of the Treatment of Male Pattern Hair Loss

53 citations , February 2020 in “Expert Opinion on Pharmacotherapy”

Finasteride and minoxidil work best together for hair loss.

research Minoxidil And Its Use In Hair Disorders: A Review

117 citations , August 2019 in “Drug Design Development and Therapy”

Minoxidil effectively treats hair loss, but use cautiously and monitor side effects.

research Morroniside Regulates Hair Growth and Cycle Transition via Activation of the Wnt/β-Catenin Signaling Pathway

25 citations , September 2018 in “Scientific Reports”

Morroniside may help hair grow and stay in its growth phase by affecting certain cell signals.

research Low-Level Laser Therapy for the Treatment of Androgenic Alopecia: A Review

41 citations , February 2018 in “Lasers in Medical Science”

Low-Level Laser Therapy (LLLT) is a safe and effective treatment for common hair loss, but more research is needed to find the best power and wavelength for treatment.

research Effectiveness of Platelet-Rich Plasma for Androgenetic Alopecia: A Review of the Literature

53 citations , January 2018 in “Skin appendage disorders”

PRP treatment helps hair growth in most cases, but more research needed.

research Evaluation of the Expression of Genes Associated with Inflammation and Apoptosis in Androgenetic Alopecia by Targeted RNA-Seq

8 citations , December 2017 in “Skin appendage disorders”

WNT7A gene expression is higher in early stages of androgenetic alopecia, showing the role of WNT pathway, apoptosis, and inflammation in the disorder.

research The Effectiveness of Treatments for Androgenetic Alopecia: A Systematic Review and Meta-Analysis

178 citations , July 2017 in “Journal of The American Academy of Dermatology”

Minoxidil, finasteride, and low-level laser light therapy effectively treat hair loss.

research Low-Level Laser Therapy as a Treatment for Androgenetic Alopecia

47 citations , January 2017 in “Lasers in Surgery and Medicine”

Low-level laser therapy may improve hair regrowth and thickness for androgenetic alopecia, but more research is needed.

research Demographics of Women with Female Pattern Hair Loss and the Effectiveness of Spironolactone Therapy

26 citations , October 2015 in “Journal of The American Academy of Dermatology”

Spironolactone may effectively treat female hair loss, especially with hyperandrogenism signs.

research Female Pattern Hair Loss: A Clinical and Pathophysiological Review

91 citations , July 2015 in “Anais Brasileiros De Dermatologia”

Female Pattern Hair Loss affects women's self-esteem and needs more research for better treatment.

research The Role of Inflammation and Immunity in the Pathogenesis of Androgenetic Alopecia

19 citations , December 2011 in “PubMed”

research Chronic Telogen Effluvium: Increased Scalp Hair Shedding in Middle-Aged Women

234 citations , December 1996 in “Journal of The American Academy of Dermatology”

Middle-aged women with chronic telogen effluvium experience increased hair shedding but usually don't get significantly thinner hair.

research Improvement in the Inflammatory Aspect of Androgenetic Alopecia: A Pilot Study with an Antimicrobial Lotion

40 citations , January 1996 in “Journal of Dermatological Treatment”

Antimicrobial lotion reduces inflammation and increases hair density in hair loss patients.

research Diagnostic and predictive value of horizontal sections of scalp biopsy specimens in male pattern androgenetic alopecia

309 citations , May 1993 in “Journal of The American Academy of Dermatology”

Horizontal scalp biopsy sections effectively diagnose and predict MPAA, with follicular density and inflammation impacting hair regrowth.

research Male Pattern Alopecia A Histopathologic and Histochemical Study

94 citations , August 1975 in “Journal of Cutaneous Pathology”

Male pattern baldness involves smaller hair follicles, larger oil glands, and other tissue changes, but not major blood supply issues.