The Role of Inflammation and Immunity in the Pathogenesis of Androgenetic Alopecia

    December 2011 in “ PubMed
    Cynthia M. Magro, Anthony M. Rossi, Jonathan C. Poe, Suveena Manhas-Bhutani, Neil S. Sadick
    TLDR Inflammation and immunity play a key role in androgenetic alopecia, with better treatment outcomes in certain immune-positive cases.
    The study investigated the role of immunity and inflammation in androgenetic alopecia (AA) in 52 women through scalp biopsies and serologic assessments. It found that many cases exhibited lymphocytic folliculitis targeting the bulge epithelium and significant IgM deposits in the epidermal basement membrane zone, often with complement activation. These changes were more pronounced in patients with positive immunoreactant profiles. Serologic tests for antibodies to androgen receptor, estrogen receptor, and cytokeratin 15 were negative. Combined therapy with minocycline, topical steroids, and red light was more effective in the positive immunoreactant group. The findings suggested an immunologically driven trigger for AA, with better treatment outcomes in cases with positive immunoreactant profiles.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results
      If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      community If You Have DUPA, PLEASE READ THIS: Everyone Should Be Scalp Biopsied

      in Research  822 upvotes 5 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Lost density 60% all over scalp in 120 days (4months)

      in Update  10 upvotes 7 months ago
      A user lost 60% hair density in 4 months, started finasteride and microneedling, and has greasy, flaky, yellowish scalp. They are awaiting biopsy results, and another user suggested trying ketoconazole shampoo.

    Similar Research

    5 / 1000+ results