Primary Cicatricial Alopecias

    April 2010 in “ Expert Review of Dermatology ”
    Adel Alsantali, Jerry Shapiro
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    TLDR The document concludes that early diagnosis and treatment are crucial for managing rare hair loss disorders and that more research is needed to improve treatment strategies.
    The document from April 2010 provides a comprehensive review of primary cicatricial alopecias (PCAs), a group of rare inflammatory disorders that result in permanent hair follicle destruction and irreversible hair loss. It categorizes PCAs into lymphocytic, neutrophilic, and mixed types, with specific conditions such as discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) being discussed in detail, including their clinical features, etiology, and treatment options. The article also covers other PCAs like frontal fibrosing alopecia (FFA), pseudopelade of Brocq (PPB), central centrifugal cicatricial alopecia (CCCA), alopecia mucinosa (AM), keratosis follicularis spinulosa decalvans (KFSD), and folliculitis decalvans (FD), providing insights into their presentation and management. The importance of early diagnosis and intervention is emphasized to prevent further hair loss, and the need for controlled clinical trials to evaluate therapeutic options is highlighted, along with the potential for technological advances to improve PCA management strategies.
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