Primary Cicatricial Alopecias

April 2010 in “ Expert Review of Dermatology ”

Adel Alsantali, Jerry Shapiro

TLDR The document concludes that early diagnosis and treatment are crucial for managing rare hair loss disorders and that more research is needed to improve treatment strategies.

The document from April 2010 provides a comprehensive review of primary cicatricial alopecias (PCAs), a group of rare inflammatory disorders that result in permanent hair follicle destruction and irreversible hair loss. It categorizes PCAs into lymphocytic, neutrophilic, and mixed types, with specific conditions such as discoid lupus erythematosus (DLE) and lichen planopilaris (LPP) being discussed in detail, including their clinical features, etiology, and treatment options. The article also covers other PCAs like frontal fibrosing alopecia (FFA), pseudopelade of Brocq (PPB), central centrifugal cicatricial alopecia (CCCA), alopecia mucinosa (AM), keratosis follicularis spinulosa decalvans (KFSD), and folliculitis decalvans (FD), providing insights into their presentation and management. The importance of early diagnosis and intervention is emphasized to prevent further hair loss, and the need for controlled clinical trials to evaluate therapeutic options is highlighted, along with the potential for technological advances to improve PCA management strategies.

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research Frontal Fibrosing Alopecia: Treatment with Oral Dutasteride and Topical Pimecrolimus

69 citations , May 2009 in “Journal of The European Academy of Dermatology and Venereology”

Oral dutasteride and topical pimecrolimus can safely and effectively treat Frontal Fibrosing Alopecia, leading to significant hair regrowth.

research Central Centrifugal Cicatricial Alopecia: Past, Present, and Future

75 citations , April 2009 in “Journal of The American Academy of Dermatology”

CCCA is a hair loss type affecting African women, possibly caused by grooming and chemicals, with various treatments and needing more research.

research Lichen Planopilaris: Retrospective Study and Stepwise Therapeutic Approach

43 citations , March 2009 in “Archives of dermatology”

No treatment showed clear superiority for lichen planopilaris.

research A Histologic Review of 27 Patients with Lichen Planopilaris

76 citations , July 2008 in “Journal of the American Academy of Dermatology”

The conclusion is that certain scalp tissue changes are characteristic of lichen planopilaris, with mucinous perifollicular fibroplasia being a new feature for diagnosis.

research Central Centrifugal Cicatricial Alopecia

72 citations , July 2008 in “Dermatologic Therapy”

CCCA is a scarring hair loss condition mainly in African descent women, possibly caused by genetics and hairstyling, treated with gentle hair care and medications.

research Cicatricial Alopecia: Classification and Histopathology

74 citations , July 2008 in “Dermatologic therapy”

Early detection and histopathology are crucial to prevent permanent hair loss in cicatricial alopecia.

research Pseudopelade of Brocq: A Review of a Rare Hair Disorder Leading to Cicatricial Alopecia

39 citations , July 2008 in “Dermatologic Therapy”

Pseudopelade of Brocq is a unique hair loss condition, but its cause and development are still not fully understood.

research Keratosis Follicularis Spinulosa Decalvans in a Family

32 citations , March 2008 in “Journal of the American Academy of Dermatology”

KFSD is a genetic disorder causing hair loss and skin issues, with no effective treatment.

research A Case-Series of 29 Patients with Lichen Planopilaris: The Cleveland Clinic Foundation Experience on Evaluation, Diagnosis, and Treatment

113 citations , July 2007 in “Journal of the American Academy of Dermatology”

The study found that steroids and tetracycline helped treat active Lichen planopilaris, and hair transplants were good for later stages.

research Lupus Erythematosus: Systemic and Cutaneous Manifestations

144 citations , September 2006 in “Clinics in Dermatology”

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

research Histopathologic Evaluation of Alopecias

90 citations , June 2006 in “The American Journal of Dermatopathology”

The document concludes that accurate diagnosis of different types of hair loss requires careful examination of hair and scalp tissue, considering both clinical and microscopic features.

research Frontal Fibrosing Alopecia: A Survey in 16 Patients

123 citations , August 2005 in “Journal of the European Academy of Dermatology and Venereology”

The study found that Frontal Fibrosing Alopecia affects a broader age range of women and early treatment can help stop hair loss.

research Modern External Beam Radiation Therapy for Refractory Dissecting Cellulitis of the Scalp

36 citations , April 2005 in “British journal of dermatology/British journal of dermatology, Supplement”

Radiation therapy is an effective treatment for severe scalp cellulitis with mild side effects and no long-term complications.

research Frontal Fibrosing Alopecia in Postmenopausal Women

179 citations , January 2005 in “Journal of The American Academy of Dermatology”

Some postmenopausal women with frontal fibrosing alopecia stopped losing hair with finasteride treatment, hinting at a possible hormonal cause.

research Medical and Surgical Therapies for Alopecias in Black Women

105 citations , June 2004 in “Dermatologic Therapy”

The document concludes that proper diagnosis and a combination of medical, hair-care, and surgical treatments are important for managing alopecia in black women.

research Alopecia Mucinosa: Report of a Case and Review

21 citations , April 2003 in “Journal of cutaneous medicine and surgery”

Alopecia mucinosa can be treated successfully with minocycline in some cases.

research Use of an 800-nm Pulsed-Diode Laser in the Treatment of Recalcitrant Dissecting Cellulitis of the Scalp

51 citations , October 2002 in “Archives of dermatology”

The document does not conclude the effectiveness of the 800-nm pulsed-diode laser for treating scalp cellulitis.

research Lymphocytic Mediated Alopecia: Histological Classification by Pattern Analysis

29 citations , March 2001 in “Clinics in Dermatology”

Steven Kossard classified lymphocyte-related hair loss into four patterns, each linked to different types of baldness.

research Elastic Tissue in Scars and Alopecia

80 citations , March 2000 in “Journal of cutaneous pathology”

The VVG stain effectively differentiates scar tissue from normal skin and helps classify types of permanent alopecia.

research Acquired Scalp Alopecia: A Review

44 citations , November 1998 in “Australasian Journal of Dermatology”

Accurate diagnosis is key for treating different kinds of hair loss, and immune response variations may affect the condition and treatment results.

research Postmenopausal Frontal Fibrosing Alopecia: A Frontal Variant of Lichen Planopilaris

329 citations , January 1997 in “Journal of the American Academy of Dermatology”

Frontal fibrosing alopecia is a hair loss condition in postmenopausal women, similar to lichen planopilaris, with ineffective treatments.

research Clinical Findings, Cutaneous Pathology, and Response to Therapy in 21 Patients With Keratosis Pilaris Atrophicans

78 citations , April 1994 in “Archives of dermatology”

The study found that Keratosis Pilaris Atrophicans is a genetic skin condition that starts in childhood, involves inflammation and scarring, and current treatments are only somewhat effective.

research Keratosis follicularis spinulosa decalvans: a family study of seven male cases and six female carriers.

41 citations , January 1992 in “Journal of medical genetics”

The study found that males with KFSD had severe skin and eye symptoms, while female carriers had milder symptoms.

research Acne Keloidalis: A Review

78 citations , June 1989 in “The Journal of dermatologic surgery and oncology”

Acne keloidalis is a chronic skin condition on the back of the neck in young black men, needing surgery for severe cases.

research Keratosis Follicularis Spinulosa Decalvans

54 citations , January 1983 in “Archives of Dermatology”

KFSD is a rare condition causing scarring hair loss, with no effective treatment known at the time of the report.