Primary Cicatricial Alopecias Are Characterized by Dysregulation of Shared Gene Expression Pathways

July 2022 in “ PNAS Nexus ”

Eddy H.C. Wang, Isha Monga, B. Sallee, James C. Chen, A.R. Abdelaziz, Rolando Pérez‐Lorenzo, Lindsey A. Bordone, Angela M. Christiano

primary cicatricial alopecias lichen planopilaris frontal fibrosing alopecia centrifugal cicatricial alopecia mast cell genes cholesterogenic pathways fibrosis immune signaling genes

Studysummary This study identified a shared gene signature in scarring alopecia subtypes, with increased mast cell presence, suggesting similar treatment approaches may be effective across these hair loss disorders.

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Research cited in this study

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research Frontal Fibrosing Alopecia Shows Robust T Helper 1 and Janus Kinase 3 Skewing

34 citations , June 2020 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, researchers observed that follicular damage and stem cell loss in frontal fibrosing alopecia may be mediated by immune attacks at the bulge region, suggesting potential for JAK/STAT-targeting treatments to prevent progression.

research Hair Loss Among Transgender and Gender-Nonbinary Patients: A Cross-Sectional Study

7 citations , May 2019 in “British Journal of Dermatology”

In this study, testosterone use in gender-minority patients was associated with significantly worse androgenetic alopecia severity scores, while feminizing hormone therapy did not significantly change hair loss severity.

research Genome-Wide Association Study in Frontal Fibrosing Alopecia Identifies Four Susceptibility Loci Including HLA-B*07:02

115 citations , March 2019 in “Nature Communications”

This study identified significant genetic associations with frontal fibrosing alopecia at four genomic loci, suggesting it is a genetically predisposed immuno-inflammatory disorder influenced by the HLA-B*07: 02 allele.

research Variant PADI3 in Central Centrifugal Cicatricial Alopecia

95 citations , February 2019 in “The New England Journal of Medicine”

This article discusses the potential genetic basis of central centrifugal cicatricial alopecia in women of African ancestry but does not provide new research results.

research Compared to Controls, Individuals with Lichen Planopilaris Have More Depression, Lower Self-Esteem, and Lower Quality of Life

16 citations , January 2019 in “Neuropsychobiology”

This study found that individuals with lichen planopilaris reported lower quality of life and self-esteem and higher depression scores compared to healthy controls.

research Tofacitinib for the Treatment of Lichen Planopilaris: A Case Series

79 citations , September 2018 in “Dermatologic therapy”

This study found that treatment with oral tofacitinib, alone or with other therapies, was associated with clinical improvement in most patients with recalcitrant lichen planopilaris.

research Photopatch And Patch Testing In 63 Patients With Frontal Fibrosing Alopecia: A Case Series

24 citations , July 2018 in “British Journal of Dermatology”

Contact allergies might contribute to frontal fibrosing alopecia.

research Fibroproliferative Genes Are Preferentially Expressed in Central Centrifugal Cicatricial Alopecia

25 citations , June 2018 in “Journal of The American Academy of Dermatology”

This study identified upregulation of genes linked to fibroproliferative disorders, such as platelet-derived growth factor and collagen genes, in patients with central centrifugal cicatricial alopecia, suggesting potential therapeutic targets.

research Frontal Fibrosing Alopecia: Regrowth Following Cessation of Sunscreen on the Forehead

26 citations , June 2018 in “Australasian Journal of Dermatology”

Stopping sunscreen use on the forehead led to hair regrowth in a woman with frontal fibrosing alopecia.

An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

research An Open-Label Pilot Study to Evaluate the Efficacy of Tofacitinib in Moderate to Severe Patch-Type Alopecia Areata, Totalis, and Universalis

130 citations , February 2018 in “Journal of Investigative Dermatology”

This study found that tofacitinib led to ≥50% hair regrowth in eight out of twelve patients with moderate to severe alopecia areata, suggesting a potential benefit for using JAK inhibitors in treating this condition.

research Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris

71 citations , October 2017 in “Journal of Investigative Dermatology”

PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

research Primary Cicatricial Alopecia

65 citations , November 2016 in “Journal of The American Academy of Dermatology”

This article reviews various types of primary cicatricial alopecias and emphasizes the importance of accurate diagnosis to improve management strategies, particularly detailing remaining lymphocytic forms and expanding on neutrophilic and mixed types.

research Primary Cicatricial Alopecia: Treatment Approaches and Classification

95 citations , November 2016 in “Journal of The American Academy of Dermatology”

This article reviews primary cicatricial alopecias, focusing on lymphocytic forms such as chronic cutaneous lupus erythematosus, according to a classification by the North American Hair Research Society, and reports no new clinical results.

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations , September 2016 in “JCI insight”

This study explored the effectiveness of the oral JAK1/2 inhibitor ruxolitinib in treating patients with moderate-to-severe alopecia areata, building on prior success with JAK inhibitors in mice, but results are not reported in this abstract.

research Alopecia Areata Is Driven by Cytotoxic T Lymphocytes and Is Reversed by JAK Inhibition

701 citations , August 2014 in “Nature medicine”

This study found that JAK inhibitors promote hair regrowth in both mice and human alopecia areata cases by blocking key immune pathways involved in disease development.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

22 citations , June 2012 in “PLOS ONE”

In this study, researchers found that impaired cholesterol biosynthesis in hair follicles may trigger an inflammatory immune response linked to primary cicatricial alopecia, providing new insights into the disorder's pathogenesis.

research The Pathogenesis of Primary Cicatricial Alopecias

150 citations , October 2010 in “The American Journal of Pathology”

This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.