Elastin Staining Patterns in Primary Cicatricial Alopecia

November 2013 in “ Journal of The American Academy of Dermatology ”

Maxwell A. Fung, Victoria R. Sharon, Mondhipa Ratnarathorn, Thomas Konia, Keira Barr, Paradi Mirmirani

primary cicatricial alopecia scalp biopsy Verhoeff elastic van Gieson staining perifollicular fibrosis central centrifugal cicatricial alopecia CCCA lichen planopilaris LPP tree trunk-shaped fibrosis scarring alopecia traction alopecia scarring hair loss

Studysummary This study reported that patterns of fibrosis identified through elastin staining may help distinguish specific forms of primary cicatricial alopecia in biopsy specimens, with certain patterns suggesting particular diagnoses.

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research Follicular Density and Ratios in Scarring and Nonscarring Alopecia

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research The Utility of Elastic Verhoeff-Van Gieson Staining in Dermatopathology

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This review discusses the significance of elastic tissue staining in dermatopathology, particularly for diagnosing primary elastic tissue disorders and other skin conditions, but reports no new clinical results.

research What's New in the Histologic Evaluation of Alopecia and Hair-Related Disorders?

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This article reviews advances in the histologic evaluation of alopecia and hair-related disorders, without presenting new clinical results.

research The HoVert Technique: A Novel Method for the Sectioning of Alopecia Biopsies

44 citations , January 2011 in “Journal of Cutaneous Pathology”

This study introduces the "HoVert" technique, which generates both vertical and horizontal sections from a single biopsy to effectively differentiate lichen planopilaris from discoid lupus erythematosus in alopecia cases.

research Psychosocial Impact of Cicatricial Alopecias

16 citations , January 2011 in “Indian Journal of Dermatology”

This study found that 73.9% of patients with cicatricial alopecia reported moderate to severe psychosocial impacts, highlighting the importance of addressing psychological aspects in treatment.

research Histopathology of Alopecia: A Clinicopathological Approach to Diagnosis

170 citations , December 2009 in “Histopathology”

This review discusses the histopathological diagnosis of scarring and non-scarring alopecias, emphasizing the importance of adequate tissue sampling and clinical information; it reports no new empirical results.

research Determinants of Marginal Traction Alopecia in African Girls and Women

94 citations , September 2008 in “Journal of the American Academy of Dermatology”

This study found that traction alopecia risk was higher in adults than children and increased further when traction was combined with chemically relaxed hair.

research Central Centrifugal Cicatricial Alopecia

72 citations , July 2008 in “Dermatologic Therapy”

This article reviews central centrifugal cicatricial alopecia in African-descent females, discussing possible causes, associated styling habits, and potential treatments, but reports no new clinical findings; the authors call for further research.

research A Histologic Review of 27 Patients with Lichen Planopilaris

76 citations , June 2008 in “Journal of the American Academy of Dermatology”

In this study, key histologic features such as mucinous perifollicular fibroplasia were identified to aid in the diagnosis of lichen planopilaris.

research Elastic Tissue in Scars and Alopecia

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This study found that the Verhoeff-Van Gieson stain effectively distinguishes scarred from non-scarred dermis and aids in classifying types of permanent alopecia based on elastic tissue patterns.

research Fibrosing Alopecia in a Pattern Distribution

158 citations , February 2000 in “Archives of dermatology”

This study reports that some patients with androgenetic alopecia may also exhibit clinical and histological features of inflammation and fibrosis, similar to those found in lichen planopilaris.