Epithelial-To-Mesenchymal Stem Cell Transition In A Human Organ: Lessons From Lichen Planopilaris

October 2017 in “ Journal of Investigative Dermatology ”

Hisayoshi Imanishi, David M. Ansell, Jeremy Chéret, Matthew Harries, Marta Bertolini, Norbert Sepp, Tamás Bı́ró, Enrique Poblet, Francisco Jiménez, J. Hardman, Sreejith Parameswara Panicker, Christopher M. Ward, Ralf Paus

epithelial-to-mesenchymal transition lichen planopilaris scarring alopecia hair follicles peroxisome proliferator-activated receptor-γ PPAR-γ agonists pioglitazone N-Acetyl-GED epithelial stem cells EMT LPP PPAR-γ Actos

Studysummary PPAR-γ agonists like pioglitazone may help manage lichen planopilaris but don't fully reverse scarring.

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Frontal Fibrosing Alopecia: A Disease Fascinating for the Researcher, Disappointing for the Clinician and Distressing for the Patient

research Frontal Fibrosing Alopecia: A Disease Fascinating for the Researcher, Disappointing for the Clinician and Distressing for the Patient

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This article reviews the pathogenesis of frontal fibrosing alopecia, highlighting the potential genetic and environmental contributions, particularly the use of sunscreens, and calls for further research into effective treatments.

research Frontal Fibrosing Alopecia: Reflections and Hypotheses on Etiology and Pathogenesis

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research Human Hair Follicle Organ Culture: Theory, Application, and Perspectives

130 citations , August 2015 in “Experimental Dermatology”

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research Epithelial–Mesenchymal Transition in Keloid Tissues and TGF-β1–Induced Hair Follicle Outer Root Sheath Keratinocytes

46 citations , July 2015 in “Wound repair and regeneration”

This study found that keloid tissues exhibit epithelial-mesenchymal transition-related changes and alterations in gene expression, implicating these processes in the pathogenesis of keloids.

research The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology

84 citations , February 2015 in “Experimental Dermatology”

This review discusses the role of PPARs in skin health, suggesting both potential benefits and adverse effects, but reports no new experimental results; the authors emphasize the need for more research to understand these pathways.

research The Use of Oral Pioglitazone in the Treatment of Lichen Planopilaris

58 citations , January 2015 in “Journal of the American Academy of Dermatology”

Pioglitazone may help treat lichen planopilaris, but more research is needed.

Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

research Human Epithelial Hair Follicle Stem Cells and Their Progeny: Current State of Knowledge, the Widening Gap in Translational Research and Future Challenges

106 citations , March 2014 in “BioEssays”

This review examines current knowledge on human epithelial hair follicle stem cells, their markers, and outlines challenges in translating findings from murine studies to human research, but does not report new experimental results.

research Advanced Inhibition of Undesired Human Hair Growth by PPARγ Modulation

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This study found that the selective PPARγ modulator GMG-43AC may inhibit unwanted hair growth by inducing catagen phase while preserving hair follicle epithelial progenitor cells, suggesting potential in anti-hirsutism therapy.

Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

research Lichen Planopilaris Treated by the Peroxisome Proliferator-Activated Receptor-γ Agonist Pioglitazone: Lack of Lasting Improvement or Cure in the Majority of Patients

33 citations , October 2013 in “Journal of The American Academy of Dermatology”

In this study, pioglitazone treatment in patients with lichen planopilaris showed limited success, with significant improvement seen in only a minority of cases.

research Lichen Planopilaris Is Characterized By Immune Privilege Collapse Of The Hair Follicle's Epithelial Stem Cell Niche

220 citations , June 2013 in “The Journal of Pathology”

This study found that immune privilege collapse in the hair follicle bulge and associated immune responses may contribute significantly to the pathogenesis of lichen planopilaris, suggesting a potential autoimmune basis for the disease.

research The CD44+ALDH+ Population of Human Keratinocytes Is Enriched for Epidermal Stem Cells with Long-Term Repopulating Ability

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Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

research Sterol Intermediates of Cholesterol Biosynthesis Inhibit Hair Growth and Trigger an Innate Immune Response in Cicatricial Alopecia

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This review discusses the pathogenesis and challenges in treating primary cicatricial alopecia, highlighting the need to understand immune protection collapse in hair follicle stem cells; it reports no new clinical results.

research Expression of Snail1 in the Fibrotic Dermis of Postmenopausal Frontal Fibrosing Alopecia: Possible Involvement of an Epithelial-Mesenchymal Transition and a Review of Japanese Patients

29 citations , February 2010 in “British Journal of Dermatology”

This study explores the expression of Snail1 in the fibrotic dermis of postmenopausal women with frontal fibrosing alopecia, suggesting a possible link to epithelial-mesenchymal transition.

research Lichen Planopilaris Treated With a Peroxisome Proliferator-Activated Receptor Gamma Agonist

105 citations , December 2009 in “Archives of dermatology”

This overview discusses primary cicatricial alopecias, focusing on lichen planopilaris, and highlights the challenges in treatment and the progressive nature of hair loss despite symptom management, without providing new clinical results.

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