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    Did you mean PPAR Agonists?
    Glossary PPAR Agonists

    activate nuclear receptors to regulate metabolism and inflammation

    PPAR Agonists, or Peroxisome Proliferator-Activated Receptor Agonists, are compounds that activate PPARs, which are nuclear receptor proteins that regulate gene expression. These receptors play a crucial role in metabolism, inflammation, and cell differentiation, making PPAR agonists valuable in treating conditions like diabetes, obesity, and certain types of hair loss, such as alopecia.

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    1. 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages 2022
    2. Peroxisome Proliferator Activated Receptors Gamma Serum levels and Gene Polymorphism in Frontal Fibrosing Alopecia: A Case Control Study Research Square (Research Square) · 2022
    3. 0866 Role of transcriptional elongation in dermal fat development Journal of Investigative Dermatology · 2025
    4. Nelfb promotes dermal white adipose tissue formation through RNA Polymerase II mediated adipogenic gene regulation Development · 2025
    5. Faculty Opinions recommendation of Hair follicle stem cell-specific PPARgamma deletion causes scarring alopecia. Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature · 2009
    6. Mechanism of PPARα agonist in alopecia areata American Journal of Translational Research · 2025 · 1 citations
    7. Peroxisome proliferator-activated receptors-mediated diabetic wound healing regulates endothelial cells’ mitochondrial function via sonic hedgehog signaling Burns & Trauma · 2025 · 5 citations
    8. Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics? Archives of dermatological research · 2015 · 60 citations
    9. PPAR-<i>γ</i> Agonists and Their Role in Primary Cicatricial Alopecia PPAR Research · 2017 · 38 citations
    10. Lichen Planopilaris Treated With a Peroxisome Proliferator–Activated Receptor γ Agonist Archives of dermatology · 2009 · 105 citations
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