The Role of PPARγ-Mediated Signalling in Skin Biology and Pathology: New Targets and Opportunities for Clinical Dermatology
March 2015
in “
Experimental Dermatology
”
TLDR PPARγ is crucial for skin health but can have both beneficial and harmful effects.
PPARγ played a crucial role in skin biology by regulating cell proliferation, differentiation, and inflammatory responses, and was expressed in various skin cells, including hair follicle cells. It influenced skin barrier permeability, lipid metabolism, and inhibited inflammatory mediators, suggesting therapeutic potential for inflammatory skin diseases. PPARγ agonists like TZDs showed benefits but had adverse effects, prompting the development of novel modulators to retain anti-inflammatory benefits while minimizing side effects. In hair biology, PPARγ was essential for hair follicle maintenance, with decreased expression linked to scarring alopecia. Despite promising preclinical results, more extensive clinical trials were needed to confirm the therapeutic potential of PPARγ modulators in skin and hair disorders.
