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Glossary Hair Follicle Epithelial Stem Cells

specialized cells that regenerate and produce new hair

Hair Follicle Epithelial Stem Cells are specialized cells located in the hair follicle that have the ability to regenerate and produce new hair. These cells play a crucial role in the growth cycle of hair, as they can differentiate into various cell types needed for hair formation and repair, making them essential for maintaining healthy hair and potentially treating conditions like alopecia.

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Research

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research (Neuro-)endocrinology of epithelial hair follicle stem cells

42 citations , March 2008 in “Molecular and Cellular Endocrinology”

This review explores the potential (neuro-)endocrine influences on hair follicle epithelial stem cell biology and emphasizes the need for more systematic research, but it provides no new empirical results.

research Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis

1 citations , July 2025 in “JCI Insight”

This study found that Krox20 marks a diverse stem cell population in mouse hair follicles, which significantly contributes to the interfollicular epidermis and regulates epidermal homeostasis.

research 621 An apple stem cell-derived extract increases epithelial stem cells number in the hair follicle bulge

September 2019 in “Journal of Investigative Dermatology”

This study found that apple stem cell extract may selectively influence hair follicle bulge stem cell biology without cytotoxic effects in an ex vivo human hair follicle organ culture.

research Characterization of Epithelial Hair Follicle Stem Cells in Lichen Planopilaris and Folliculitis Decalvans Through Keratin 19 Expression

December 2025 in “American Journal of Dermatopathology”

Keratin 19 may help diagnose and treat certain types of permanent hair loss.

Environmental Pathobiology of Frontal Fibrosing Alopecia: Does Linalool Promote FFA Development and Progression?

research 382 Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge?

November 2022 in “The journal of investigative dermatology/Journal of investigative dermatology”

This study suggests that allergens like linalool found in personal care products may contribute to the pathobiology of frontal fibrosing alopecia by affecting immune responses and stem cell function in hair follicles.

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Community Join

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community Researchers working on ways to regenerate lost hair from stem cells identified a recipe for normal hair regeneration in the lab. “A method for cyclical regeneration of hair follicles from hair follicle stem cells and will help make hair follicle regeneration therapy a reality in the near future.”

263 upvotes 5 years ago

Hair loss treatments like finasteride, minoxidil, and hair transplants have side effects and limitations. There is hope for future advancements in stem cell therapy and hair follicle regeneration, though skepticism about their effectiveness and timeline persists.

community DHT Isn’t the Only Factor in Hair Loss and That Might Be the Key to a Real Cure

373 upvotes 6 months ago

Hair loss involves more than just DHT, with genetic factors like TRPS affecting hair follicles. Treatments such as Amplifica's AMP-601 and AMP-303 target stem cells for potential hair growth solutions.

community Quote from Pelage (PP-405) Spokesperson...

122 upvotes 11 months ago

Pelage is developing a topical hair follicle stem cell therapy, PP405, for non-scarring alopecias like androgenetic alopecia, with Phase III trials planned and a potential market launch by 2027. The treatment may not require continuous use after initial regrowth.

community Hair cloning breakthrough, this might just be the big one ?

418 upvotes 6 months ago

Japanese scientists discovered ABM cells, enabling successful human hair follicle cloning, potentially curing hair loss. The treatment may be available in Japan by 2028, but it will be expensive and require travel.

community Proof DHT is not the main cause of hair loss. TRPS1 Gene and Protein might be. PP405 won’t work. AMP-303 might!

153 upvotes 6 months ago

Hair loss may be linked to the TRPS1 gene and protein, not just DHT. Amplifica's AMP-303 targets mesenchymal stem cells and shows promise in treating hair loss, unlike Pelage's PP405.

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Learn

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learn Stem Cell Factor

learn Hair Multiplication

extract, clone, and reinsert your own hair cells

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signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

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