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    Glossary Hair Follicle Epithelial Stem Cells

    specialized cells that regenerate and produce new hair

    Hair Follicle Epithelial Stem Cells are specialized cells located in the hair follicle that have the ability to regenerate and produce new hair. These cells play a crucial role in the growth cycle of hair, as they can differentiate into various cell types needed for hair formation and repair, making them essential for maintaining healthy hair and potentially treating conditions like alopecia.

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    1. (Neuro-)endocrinology of epithelial hair follicle stem cells Molecular and Cellular Endocrinology · 2008 · 42 citations
    2. Hair follicle epithelial stem cells contribute to interfollicular epidermis during homeostasis JCI Insight · 2025 · 1 citations
    3. 621 An apple stem cell-derived extract increases epithelial stem cells number in the hair follicle bulge Journal of Investigative Dermatology · 2019
    4. Characterization of Epithelial Hair Follicle Stem Cells in Lichen Planopilaris and Folliculitis Decalvans Through Keratin 19 Expression American Journal of Dermatopathology · 2025
    5. Interfollicular epidermal stem-like cells for the recreation of the hair follicle epithelial compartment Stem cell research & therapy · 2021 · 14 citations
    6. 382 Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge? 2022
    7. Lichen planopilaris is characterized by immune privilege collapse of the hair follicle's epithelial stem cell niche The Journal of Pathology · 2013 · 220 citations
    8. ESDR382 - Environmental pathobiology of frontal fibrosing alopecia (FFA): Does linalool promote FFA development and progression by inducing epithelial hair follicle stem cell damage and MICA expression in the bulge? 2022
    9. Corneal epithelial‐like transdifferentiation of hair follicle stem cells is mediated by pax6 and β‐catenin/Lef‐1 Cell Biology International · 2009 · 20 citations
    10. Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms Cancer Research · 2019
    11. Abstract LB-039: Chronic inflammation-mediated contribution of bone marrow-derived epithelial cells and hair follicle stem cells to development of cutaneous neoplasms Tumor Biology · 2019
    12. Human epithelial hair follicle stem cells and their progeny: Current state of knowledge, the widening gap in translational research and future challenges BioEssays · 2014 · 106 citations
    13. Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro European Journal of Cell Biology · 2010 · 42 citations
    14. Human epithelial stem cell survival within their niche requires “tonic” cannabinoid receptor 1‐signalling—Lessons from the hair follicle Experimental Dermatology · 2021 · 14 citations
    15. CD49fhigh Defines a Distinct Skin Mesenchymal Stem Cell Population Capable of Hair Follicle Epithelial Cell Maintenance 2019 · 11 citations
    16. Keratin 15 Promoter Targets Putative Epithelial Stem Cells in the Hair Follicle Bulge Journal of Investigative Dermatology · 2003 · 387 citations
    17. Corneal Limbal Microenvironment Can Induce Transdifferentiation of Hair Follicle Stem Cells into Corneal Epithelial-like Cells Stem Cells · 2008 · 162 citations
    18. Multi-potentiality of a new immortalized epithelial stem cell line derived from human hair follicles In vitro cellular & developmental biology. Animal · 2008 · 34 citations
    19. Pigment epithelium‑derived factor short peptides facilitate full‑thickness cutaneous wound healing by promoting epithelial basal cell and hair follicle stem cell proliferation Experimental and Therapeutic Medicine · 2017 · 6 citations
    20. 09-P006 Epithelial–mesenchymal interactions promote hair follicle neogenesis and a new stem cell niche in adult corneal epithelium Mechanisms of Development · 2009
    21. Limbal microenvironment can induce transdifferentiation of hair follicle stem cells into corneal epithelial‐like cells Acta Ophthalmologica · 2008
    22. Corrigendum to “Endocrine controls of primary adult human stem cell biology: Thyroid hormones stimulate keratin 15 expression, apoptosis, and differentiation in human hair follicle epithelial stem cells in situ and in vitro” [Eur. J. Cell Biol. (2010) 769–777] European Journal of Cell Biology · 2012 · 1 citations
    23. Mapping the expression of epithelial hair follicle stem cell‐related transcription factors LHX2 and SOX9 in the human hair follicle Experimental Dermatology · 2015 · 33 citations
    24. Spatiotemporal atlas resolves the mesenchymal-epithelial stem cell axis governing human hair follicle aging and pathology bioRxiv (Cold Spring Harbor Laboratory) · 2026
    25. Hair Follicle Stem Cell SLC3A2 Regulates Epithelial Regenerative Properties Journal of Investigative Dermatology · 2025
    26. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations Journal of Clinical Investigation · 2011 · 178 citations
    27. Peroxisome proliferator-activated receptor-γ signalling protects hair follicle stem cells from chemotherapy-induced apoptosis and epithelial–mesenchymal transition 2021 · 19 citations
    28. Transdifferentiation of corneal epithelium: evidence for a linkage between the segregation of epidermal stem cells and the induction of hair follicles during embryogenesis. The International Journal of Developmental Biology · 2004 · 55 citations
    29. Transdifferentiation of rat hair follicle stem cells to epithelium-like cells induced by stroma of limbus corneae Di-san junyi daxue xuebao · 2008
    30. 549 Temporary cell cycle arrest in human scalp hair follicles and their epithelial stem cells by ALRN-6924: A novel strategy to selectively protect p53-wildtype cells against paclitaxel-induced alopecia Journal of Investigative Dermatology · 2022 · 1 citations