Expression of Peroxisome Proliferator Activated Receptors (PPARs) in Human Hair Follicles and PPARα Involvement in Hair Growth

October 2000 in “ Acta dermato-venereologica ”

Nelly Billoni, Bruno Buan, Brigitte Gautier, Christine Collin, O Gaillard, Yann F. Mahé, Bruno Bernard

PPAR alpha PPAR delta PPAR gamma hair follicles dermal cells epithelial cells clofibrate PPAR alpha ligand hair follicle survival hair growth PPARα PPARδ PPARγ

TLDR PPAR alpha may help in hair growth and could be a target for treatment.

The study investigated the expression of PPAR alpha, delta, and gamma in human hair follicles and found that these receptors were present in both dermal and epithelial cells. It also examined the effect of clofibrate, a PPAR alpha ligand, on hair follicle survival in culture, noting a beneficial effect within a specific concentration range. This suggested that PPAR alpha could play a significant role in regulating hair growth.

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