The Role of Nuclear Hormone Receptors in Cutaneous Wound Repair

December 2014 in “ Cell Biochemistry and Function ”

Sandra Rieger, Hengguang Zhao, Paige Martin, Koichiro Abe, Thomas S. Lisse

nuclear hormone receptors cutaneous wound repair fibroplasia angiogenesis estrogen androgen retinoid receptors vitamin D receptor VDR peroxisome proliferator-activated receptors PPARs glucocorticoids LXR RORyt NHRs wound healing skin repair vitamin D

TLDR Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

The document from December 22, 2014, reviews the role of nuclear hormone receptors (NHRs) in cutaneous wound repair, emphasizing their regulation of processes like fibroplasia and angiogenesis. It discusses the effects of estrogen, androgen, and retinoid receptors on wound healing, noting that estrogen enhances healing, androgens impair it, and retinoids have complex effects. The review also covers the roles of the vitamin D receptor (VDR) and peroxisome proliferator-activated receptors (PPARs), with VDR-null mice showing impaired healing and PPARs being essential for epidermal injury repair. Additionally, it mentions the potential negative impact of glucocorticoids and the need for further research on less-characterized NHRs like LXR and RORyt. The document concludes that a deeper understanding of NHRs could lead to improved therapies for tissue repair and related conditions. No conflicts of interest were declared, and the work was funded by the National Institute of General Medical Sciences and the US Department of Army.

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