Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing

    September 2002 in “ ˜The œJournal of clinical investigation/˜The œjournal of clinical investigation ”
    Gillian S. Ashcroft, Stuart J. Mills
    TLDR Blocking testosterone speeds up wound healing in males.
    The study found that androgen receptors (AR) played a significant role in inhibiting wound healing in C57BL/6 mice, with increased AR expression in various skin cells during early wound healing stages. Castration accelerated healing, reduced wound areas, and increased collagen deposition, indicating that male gonadal steroids, particularly testosterone, inhibited healing by directly affecting epidermal/dermal cells or the inflammatory response. Reduced TNF-α expression and inflammation in castrated mice implicated TNF-α as a key factor regulated by gonadal steroids. Human studies supported these findings, showing slower healing in elderly males compared to females, linked to higher testosterone levels and increased TNF-α. Blocking AR with flutamide mimicked castration effects, reducing inflammation and accelerating healing, suggesting testosterone delays wound healing by enhancing inflammation through AR.
    Discuss this study in the Community →

    Research cited in this study

    3 / 3 results

    Related Community Posts Join

    6 / 1000+ results

      community Methods Of Staying Safe On Ru58841 - My 2 Cents

      in Research/Science  22 upvotes 9 months ago
      RU58841 is used topically to prevent hair loss by blocking DHT, with suggestions to drink grapefruit juice, take breaks, avoid microneedling, and use lower concentrations to reduce side effects. Users discuss applying it at night to minimize systemic absorption.

      community Minoxidil is a 5ar inhibitor according to research

      in Research/Science  150 upvotes 2 weeks ago
      Minoxidil may inhibit androgen receptors and affect hormonal pathways, potentially explaining its effectiveness in treating androgenetic alopecia (AGA). Users discuss its varying effectiveness on scalp versus facial hair and note fewer side effects with topical use compared to oral.

      community How effective is spironolactone?

      in Transgender  6 upvotes 3 years ago
      A 21-year-old MTF individual is experiencing rapid hair thinning and is currently on estradiol valerate. They are inquiring about the effectiveness of spironolactone for hair loss, despite being aware of its serious side effects.

      community [30M] My Aggressive Hair Loss Protocol – 5 Years In, Still Full Coverage

      in Treatment  25 upvotes 4 months ago
      A 30-year-old man shares his successful hair loss protocol, which includes finasteride, Nizoral shampoo, low-level laser therapy, microneedling, and past use of oral minoxidil. He plans to consider dutasteride and possibly hair transplants in the future, while advising caution with crown transplants before age 35.

      community Pyrilutamide ,the molecule’s true nature

      in Research  302 upvotes 1 year ago
      Pyrilutamide is a selective AR antagonist with a high binding affinity, making it effective in competing with DHT for androgen receptors. The 1% concentration is more effective than the 0.5%, but the latter may suffice for mild hair loss; the drug is considered a good option for those avoiding 5AR blockers due to side effects.

      community Update: Chest discomfort from RU58841

      in Update  33 upvotes 1 year ago
      A user experienced severe chest pains and shortness of breath after using RU58841 for hair loss and was advised by a doctor that blocking androgens can weaken the heart. They decided to continue with finasteride, minoxidil, and a hair transplant instead.

    Similar Research

    5 / 1000+ results