Regulatory Roles of Androgens in Cutaneous Wound Healing

January 2003 in “ Thrombosis and Haemostasis ”

Stephen C. Gilliver, Fcw Wu, Gillian S. Ashcroft

androgens testosterone cutaneous wound healing inflammation androgen receptors keratinocytes fibroblasts estrogens clot formation wound remodeling castration

Studysummary This review discusses how androgens may regulate wound healing and inflammation, noting that testosterone appears to inhibit healing and promote inflammation, but it reports no new clinical results. Our plain-language summary of this paper — not a Tressless recommendation.

The document from 2003 reviews the role of androgens, such as testosterone, in cutaneous wound healing, indicating that they may inhibit wound repair and promote inflammation. Androgen receptors are expressed by cells involved in the healing process, including inflammatory cells, keratinocytes, and fibroblasts. While estrogens are noted to have a positive effect on wound healing, testosterone is suggested to have a detrimental effect. The review covers the influence of androgens on all phases of wound healing, from clot formation to wound remodeling. It also mentions that elderly males with higher testosterone levels experience slower wound healing compared to females, and studies in mice have shown that castration can lead to accelerated wound healing. The document underscores the need for further research to fully understand the specific roles and mechanisms of androgens in human wound repair.

View this study on thieme-connect.de →

Discuss this study in the Community →

Research cited in this study

14 / 14 results

research Cutaneous Androgen Metabolism: Basic Research And Clinical Perspectives

233 citations , November 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

This review explores androgen metabolism in the skin, highlighting enzyme localization and potential implications for treating androgen-dependent skin conditions, but it reports no new clinical results.

Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

research Androgen-Inducible TGF-β1 from Balding Dermal Papilla Cells Inhibits Epithelial Cell Growth: A Clue to Understanding Paradoxical Effects of Androgen on Human Hair Growth

190 citations , October 2002 in “The FASEB journal”

In this study, androgen did not affect keratinocyte growth in coculture with androgenetic alopecia-derived dermal papilla cells, but did significantly suppress keratinocyte growth when androgen receptor was overexpressed in the papilla cells.

research Androgen Receptor-Mediated Inhibition of Cutaneous Wound Healing

108 citations , September 2002 in “The Journal of clinical investigation/The journal of clinical investigation”

This study found that reducing testosterone levels in male mice accelerates wound healing and decreases inflammation, suggesting a potential therapeutic target for improving wound repair in elderly males.

research Contribution of Androgens to Chronic Allograft Nephropathy Is Mediated by Dihydrotestosterone

25 citations , November 2001 in “Kidney International”

This study suggests that dihydrotestosterone plays a key role in the development of chronic allograft nephropathy, and inhibiting androgens may improve long-term kidney transplant outcomes.

research 17β-Estradiol and ICI-182780 Regulate the Hair Follicle Cycle in Mice Through an Estrogen Receptor-α Pathway

71 citations , February 2000 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism”

This study found that topical estradiol inhibits hair growth in mice by preventing the hair follicle's transition from resting to growth phase, a process reversible with an estrogen receptor antagonist.

research Intracrinology and the Skin

82 citations , January 2000 in “Hormone Research in Paediatrics”

This study describes the enzymatic processes through which DHEA is converted to active sex steroids in human skin, highlighting an androgenic effect on sebaceous glands and estrogenic effects in the vagina.

research Roles of Testosterone in the Growth of Keratinocytes Through Bald Frontal Dermal Papilla Cells

21 citations , January 1999 in “Endocrine”

research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands

45 citations , September 1998 in “Journal of Investigative Dermatology”

This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.

research Evidence of Heterogeneity and Quantitative Differences of the Type 1 5α-Reductase Expression in Cultured Human Skin Cells: Evidence of Its Presence in Melanocytes

83 citations , January 1998 in “Journal of Investigative Dermatology”

In this study using human cell cultures, type 1 5α-reductase was found to vary in both protein heterogeneity and expression levels across different types of skin cells.

Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

research Finasteride Inhibits 5α-Reductase Activity in Human Dermal Fibroblasts: Prediction of Its Therapeutic Application in Androgen-Related Skin Diseases

3 citations , October 1995 in “International Journal of Dermatology”

This study confirms that finasteride inhibits the conversion of testosterone to dihydrotestosterone in human dermal fibroblasts, suggesting potential therapeutic use for androgen-related skin disorders.

research Androgen Induction of Follicular Epithelial Cell Growth Is Mediated via Insulin-like Growth Factor-I from Dermal Papilla Cells

173 citations , July 1995 in “Biochemical and biophysical research communications”

This study suggests that IGF-I may mediate androgen-induced hair growth in outer root sheath cells cocultured with beard dermal papilla cells.

research The Control of Hair Growth: An Overview

62 citations , July 1993 in “Journal of Investigative Dermatology”

Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.

research Is Increased 5α-Reductase Activity a Primary Phenomenon in Androgen-Dependent Skin Disorders?

39 citations , July 1987 in “Journal of Investigative Dermatology”

research Regulation of Androgen Receptor and 5α-Reductase in the Skin of Normal and Hirsute Women

35 citations , May 1986 in “Clinics in endocrinology and metabolism”

This study concludes that high skin 5α-reductase activity may contribute to hirsutism, but the specific regulatory mechanisms and genetic factors remain unclear.