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Glossary Castration

surgical removal of testicles in males

Castration, also known as neutering or orchiectomy, is the surgical removal of the testicles in males. This procedure is commonly performed on animals to prevent reproduction and reduce aggressive behavior, but it can also be done in humans for medical reasons such as hormone-related cancers.

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Research

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research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations , August 2011 in “Cancer research”

This study found that castration-resistant prostate cancers resistant to CYP17A1 inhibitors may still depend on steroids and could respond to therapies targeting de novo intratumoral steroid synthesis.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study found that despite the presence of steroidogenesis inhibitors, CRPC tumor cells adapt to continue synthesizing androgens, suggesting a need for more effective androgen axis targeting.

research Prevention and treatment of experimental prostate cancer in lobund-wistar rats. I. Effects of estradiol, dihydrotestosterone, and castration

31 citations , January 1989 in “The Prostate/The prostate”

This study found that early treatment with estradiol or dihydrotestosterone significantly reduced prostate adenocarcinoma development in Lobund-Wistar rats, while later treatments were ineffective.

research Genetic variants in AR and SHBG and resistance to hormonal castration in prostate cancer

6 citations , February 2013 in “Medical Oncology”

In this study, researchers reported that the SHBG +5790 G>A polymorphism was associated with an increased risk of developing resistance to hormonal castration in advanced prostate cancer patients.

research Exogenous testosterone, finasteride and castration effects on testosterone, insulin, zinc and chromium in adult male rats.

4 citations , January 2013 in “PubMed”

In this study, testosterone and finasteride were found to increase insulin and zinc levels while decreasing chromium levels in male adult rats, suggesting potential effects on the glucose cycle.

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community Someone told me it is the increase in estradiol and estrogen from more free t that makes dht blockers work?

6 months ago

Finasteride and its effects on hair loss, with discussions on the role of estradiol and estrogen. Users debate whether increased estrogen from DHT blockers contributes to hair regrowth, with concerns about potential side effects like chemical castration.

community Natural finasteride for male deers

in Satire 241 upvotes 10 months ago

The conversation humorously discusses hair loss treatments, including minoxidil and finasteride, with a satirical suggestion of using fence castration as a natural finasteride for male deer. Participants joke about the side effects and effectiveness of these treatments.

community Couldnt you just clone yourself and have infinite hair to harvest for a transplant?

78 upvotes 1 year ago

The conversation humorously discusses the idea of cloning oneself for hair transplants, with suggestions of lobotomizing and castrating the clone. It includes various satirical and absurd comments about using clones for personal benefits beyond hair, such as companionship and organ donation.

community What would an actual nuclear stack look like?

42 upvotes 4 months ago

The conversation discusses various treatments for hair loss, including high doses of dutasteride, oral minoxidil, RU58841, microneedling, ketoconazole shampoo, and other supplements like pumpkin seed oil and multivitamins. It also touches on more extreme measures like estrogen therapy and castration, with some users emphasizing the importance of overall health and nutrition.

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