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GlossaryCastration

surgical removal of testicles in males

Castration, also known as neutering or orchiectomy, is the surgical removal of the testicles in males. This procedure is commonly performed on animals to prevent reproduction and reduce aggressive behavior, but it can also be done in humans for medical reasons such as hormone-related cancers.

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Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors

402 citations, August 2011 in “Cancer research”

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

research Steroidogenesis Inhibitors Alter But Do Not Eliminate Androgen Synthesis Mechanisms During Progression to Castration-Resistance in LNCaP Prostate Xenografts

57 citations, April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

research Prevention and Treatment of Experimental Prostate Cancer in Lobund-Wistar Rats: Effects of Estradiol, Dihydrotestosterone, and Castration

31 citations, January 1989 in “The Prostate/The prostate”

Estradiol and castration reduced prostate cancer development in rats when applied at early stages, but were ineffective after cancer was established.

research Effect of Castration and Finasteride on Urinary Oxalate Excretion in Male Rats

23 citations, January 1998 in “Urological research”

Castration and finasteride lower urinary oxalate in male rats, potentially treating urolithiasis.

research Genetic Variants in AR and SHBG and Resistance to Hormonal Castration in Prostate Cancer

6 citations, February 2013 in “Medical Oncology”

Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.

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community 4 months before and after. From a Norwood 9 to a -1. He's been on Dutasteride RU58841 and Minoxidil but the best results came after castration.

in Satire 386 upvotes 2 years ago

A user's claim that they have reversed their hair loss with the treatments Dutasteride RU58841, Minoxidil and castration; however, other users are skeptical of this claim.

community Taking Topical Minoxidil Orally Week 14

in Satire 2 years ago

Taking Minoxidil topically for hair loss and the results, which included jokes about castration, Daenerys Targaryenism, and a hair system. People in the conversation also shared positive affirmations and humorous comments.

community Sometimes just, slowing the process or stopping it on its tracks is enough. :)

in Progress Pictures 10 upvotes 1 year ago

The post discusses a user's hair loss treatment involving Dutasteride 2.5 mg 5 times per week, Finasteride 1mg 4 times per week, RU58841 daily, and Minoxidil twice daily. A reply suggests that the combination is excessive, particularly the use of both Dutasteride and Finasteride, and labels it as a "chemical castration protocol".

community Hair Loss Treatment Iceberg Chart

in Satire 1380 upvotes 2 years ago

Hair loss treatments discussed include Minoxidil, Finasteride, RU58841, ass hair transplant, topical Viagra, castration, and transitioning to female. A user mentions an experimental drug called M4U-5 (Mousteride) that turns you into a mouse.

community What’s your nuclear protocol???

in Chat 19 upvotes 1 year ago

People discussed their intense hair loss treatments, including the use of dutasteride, RU58841, minoxidil, tretinoin, essential oils, microneedling, and various topical sprays. Some users reported success with these methods in preventing hair loss and stimulating hair growth.

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