Genetic Variants in AR and SHBG and Resistance to Hormonal Castration in Prostate Cancer

    February 2013 in “ Medical Oncology ”
    Cátia Monteiro, Marta Velho Sousa, Ricardo Ribeiro, Joaquina Maurício, Avelino Fraga, Rui Medeiros
    Image of study
    TLDR Certain genetic variants increase the risk of resistance to hormone therapy in prostate cancer patients.
    The study involved 203 advanced prostate cancer patients undergoing hormonal castration therapy (HCT) and explored the link between genetic variations in the androgen receptor (AR) and sex hormone-binding globulin (SHBG) genes and resistance to HCT. It was found that individuals with the homozygous GG genotype of the SHBG +5790 G>A polymorphism had a significantly higher risk (Hazard Ratio (HR) 1.9, 95% Confidence Interval (CI) 1.1-3.3, P = 0.019) of developing resistance to HCT. Furthermore, a high AR pathway activation genetic profile, which includes the AR +1733 G>A polymorphism, also indicated an increased risk (HR 1.9, 95% CI 1.1-3.1, P = 0.015). The study concluded that these genetic variants are associated with castration-resistant prostate cancer and could potentially serve as markers to predict the efficacy of HCT in patients.
    Discuss this study in the Community →

    Research cited in this study

    2 / 2 results

    Related Community Posts Join

    6 / 1000+ results

      community GT20029 China Phase II Trial For AGA Reached Primary Endpoint

      in Research/Science  136 upvotes 7 months ago
      The GT20029 tincture, a topical androgen receptor degrader, showed significant hair growth and good safety in a China Phase II trial for male androgenetic alopecia (AGA), with the 1% dose twice weekly identified as optimal. The company plans to initiate Phase III trials in China and Phase II in the U.S., and the treatment also shows promise for acne.
      Diffuse hair loss and scalp biopsies

      community Diffuse hair loss and scalp biopsies

      in Research  692 upvotes 3 months ago
      Scalp biopsies are crucial for diagnosing hair loss conditions like Diffuse Unpatterned Alopecia (DUPA) and retrograde hair loss, as treatments like finasteride and dutasteride may not be effective if other conditions are present. Combining PPAR-GAMMA agonists with retinoids could improve treatments for conditions like Lichen Planopilaris.

      community Why is it that low testosterone causes hair loss as well? How can I be balding?

      in Chat  158 upvotes 7 months ago
      The conversation discusses the confusion over low testosterone potentially causing hair loss, with users sharing personal experiences and knowledge about hair loss treatments like Finasteride. Some users suggest that hair follicle sensitivity to DHT, not testosterone levels, is the key factor in balding, and others discuss the side effects of hair loss medications.

      community Why is Kevin Mann (Haircafe) Hated?

      in Chat  62 upvotes 1 year ago
      Hair loss treatments, including microneedling, minoxidil, finasteride and RU58841; the efficacy of these treatments; criticisms of Kevin Mann's content related to his selective data presentation and biases towards certain treatments; and other topics such as DHT being labeled a "trash hormone" and critiques of other hairloss YouTubers.

    Similar Research

    5 / 1000+ results