research Low-Dose Dimethyl Sulfoxide Suppresses Androgen Receptor and Its Splice Variant AR-V7 in Castration-Resistant Prostate Cancer Cells
Low-dose DMSO may help treat castration-resistant prostate cancer by reducing key cancer cell receptors.
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research Systemic Inflammatory Biomarkers In Alopecia Areata: The Role Of SII, SIRI, And CRP/Albumin Ratio
Alopecia areata patients have higher systemic inflammation, even in mild cases.
research Intratumoral De Novo Steroid Synthesis Activates Androgen Receptor in Castration-Resistant Prostate Cancer and Is Upregulated by Treatment with CYP17A1 Inhibitors
Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.
research Steroidogenesis Inhibitors Alter But Do Not Eliminate Androgen Synthesis Mechanisms During Progression to Castration-Resistance in LNCaP Prostate Xenografts
Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.
research Redefining Hormone Resistance in Prostate Cancer
The conclusion suggests that prostate cancer should be classified by castration status and that new therapies targeting androgen receptor signaling show promise.
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