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GlossaryCastration (Bilateral Orchiectomy)

surgical removal of testicles in males

Castration, also known as neutering or orchiectomy, is the surgical removal of the testicles in males. This procedure is commonly performed on animals to prevent reproduction and reduce aggressive behavior, but it can also be done in humans for medical reasons such as hormone-related cancers.

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research Identifying 17-β-HSD3 Deficiency in Patients with Karyotype 46,XY Misdiagnosed with Androgen Insensitivity Syndrome: A Pediatric Case Report

August 2025 in “American Journal of Case Reports”

Accurate diagnosis and early specialist referral are crucial for managing 46,XY Disorders of Sex Development.

research Interstitial Cell Tumor in a Black-and-White Ruffed Lemur (Varecia Variegatus Variegatus)

3 citations , June 2001 in “Journal of Zoo and Wildlife Medicine”

The lemur's testicular tumor was removed, improving its coat and behavior, with no signs of cancer spread.

research Hyperadrenocorticism in Ferrets

6 citations , January 2013

Hyperadrenocorticism in ferrets is linked to neutering and indoor housing, and is best treated with surgery and a deslorelin implant.

research Semen Cryopreservation in Testicular Cancer: Before or After Orchidectomy?

February 2026 in “Andrology”

Post-orchidectomy semen has better DNA integrity for fertility treatments.

research Effects of Flutamide and Finasteride on Rat Testicular Descent

143 citations , August 1991 in “Endocrinology”

Androgens, like testosterone, are crucial for early testicular descent in rats.

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community 2 year progress on fin, min, ru, dermarolling, nizoral. Experienced low libido. AMA

in Progress Pictures 74 upvotes 3 years ago

A user's experience with treating their hair loss using finasteride, minoxidil, RU58841, dermarolling, and nizoral; specifically discussing dosage levels of the medications and effects on libido.

community Treatment of Finasteride Induced Gynecomastia (Male breast tissue growth)

in Finasteride/Dutasteride 16 upvotes 5 years ago

Finasteride can cause gynecomastia, which may be reversible by stopping the drug and using selective estrogen receptor modulators (SERMs) like tamoxifen. Lifestyle changes such as weight loss and avoiding alcohol can also help, but surgery may be needed if the condition persists.

community Hairline receding again after stopping fin due to gyno – need advice on restarting (topical vs low dose oral)

Dean in General 79 upvotes 8 months ago

The user experienced hairline recession after stopping finasteride due to developing gyno and is seeking advice on whether to restart with a lower oral dose or try a topical solution with minoxidil and finasteride. They are looking for a safe and effective way to manage hair loss without worsening the gyno.

community Reasonable and safe stack? Bloodwork within.

in Minoxidil 1 upvotes 2 years ago

A 26-year-old male is using a combination of clomiphene, minoxidil, tadalafil, bupropion, and lisdexamfetamine to address low testosterone, ED, depression, and focus issues. He seeks input on the safety and efficacy of this regimen, which also includes magnesium, zinc, and fish oil supplements.

community About to throw in towel. I just don't know anymore

in Treatment 9 upvotes 9 months ago

The user is experiencing severe side effects from finasteride, including sleep issues, depression, and gynecomastia, and is considering stopping the medication. They are exploring other treatments like RU58841 and dutasteride but are hesitant due to potential side effects.

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