Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands

The study focused on the activity of the enzyme 17β-Hydroxysteroid Dehydrogenase (17β-HSD) in human sebaceous glands (SG), particularly the type 2 isozyme, to understand its role in acne development. Researchers found that the oxidative activity of the type 2 isozyme of 17β-HSD was the predominant reaction in SG, with a higher activity in non-acne-prone regions compared to facial regions. The enzyme favored oxidation over reduction, which could protect against the effects of potent androgens in vivo. The study also observed that the oxidative to reductive ratio of 17β-HSD was lower in SG from acne-prone areas, suggesting regional differences in androgen metabolism. The type 2 isozyme's activity was not inhibited by 13-cis retinoic acid. These findings imply that targeting the oxidative activity of 17β-HSD may be a potential strategy for treating acne and other related skin conditions. The research was supported by various grants, including a Dermatology Foundation Clinical Career Development Award, the Pennsylvania State University Dermatology Research Endowment Fund, and NIH grant K08AR02018.