Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands

September 1998 in “ Journal of Investigative Dermatology ”

Diane Thiboutot, P.J. Martin, Lazaros Volikos, Kathyrn Gilliland

17β-Hydroxysteroid Dehydrogenase 17β-HSD type 2 isozyme sebaceous glands acne androgens oxidative activity reductive activity 13-cis retinoic acid androgen metabolism 17β-HSD type 2 isozyme sebaceous glands acne androgens oxidative activity reductive activity isotretinoin androgen metabolism

Studysummary This study found that sebaceous glands predominantly exhibit oxidative activity of the type 2 17β-hydroxysteroid dehydrogenase isozyme, which is not inhibited by 13-cis retinoic acid.

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