Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases
February 2016
in “
Current Medicinal Chemistry
”
androgen-dependent diseases prostate cancer benign prostatic hyperplasia DHT dihydrotestosterone steroidal molecules non-steroidal molecules 5α-reductase inhibitors type 1 isozymes type 2 isozymes testosterone reduction androgen production 17β-HSD5 4-azasteroidal derivatives finasteride dutasteride phytopharmaceuticals pregnenolone derivatives dehydroepiandrosterone derivatives progesterone derivatives CYP17 inhibitors non-steroidal androgen receptor antagonists androgenic alopecia Propecia Avodart
Studysummary This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.
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