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    Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases

    February 2016 in “ Current Medicinal Chemistry ”
    Marisa Cabeza, Araceli Sánchez-Márquez, Mariana Garrido … Eugene Bratoeff
    Studysummary This review discusses various targets for treating prostate cancer and benign prostatic hyperplasia and reports on recent studies of new compounds and 5α-reductase inhibitors, but provides no new experimental results.
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    Research cited in this study 12

    1. New Ester Derivatives of Dehydroepiandrosterone as 5α-Reductase Inhibitors Steroids · 2011
    2. Novel C-6 Substituted and Unsubstituted Pregnane Derivatives as 5α-Reductase Inhibitors and Their Effect on Hamster Flank Organs Diameter Size Steroids · 2009
    3. In Vivo and In Vitro Effect of Novel 4,16-Pregnadiene-6,20-Dione Derivatives as 5α-Reductase Inhibitors The Journal of Steroid Biochemistry and Molecular Biology · 2008
    4. Biological Activity of Novel Progesterone Derivatives Having Bulky Ester Side Chains at C-3 Steroids · 2008
    5. Androgen Biosynthetic Pathways in the Human Prostate Baillière's best practice and research in clinical endocrinology and metabolism/Baillière's best practice & research. Clinical endocrinology & metabolism · 2008
    6. Recent Advances in the Chemistry and Pharmacological Activity of New Steroidal Antiandrogens and 5α-Reductase Inhibitors Current Medicinal Chemistry · 2005
    7. New 5α-Reductase Inhibitors: In Vitro and In Vivo Effects Steroids · 2005
    8. Marked Suppression of Dihydrotestosterone in Men with Benign Prostatic Hyperplasia by Dutasteride, a Dual 5α-Reductase Inhibitor ˜The œJournal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism · 2004
    9. Pharmacokinetic Parameters and Mechanisms of Inhibition of Rat Type 1 and 2 Steroid 5α-Reductases: Determinants for Different In Vivo Activities of GI198745 and Finasteride in the Rat Biochemical Pharmacology · 2001
    10. Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase Bioorganic & Medicinal Chemistry · 1997
    11. Finasteride: A Slow-Binding 5-Alpha-Reductase Inhibitor Biochemistry · 1993
    12. Species Differences in Prostatic Steroid 5α-Reductases of Rat, Dog, and Human Endocrinology · 1985