Novel Agents for the Treatment of Alopecia

    December 1998 in “ Seminars in Cutaneous Medicine and Surgery ”
    Marty E. Sawaya
    Image of study
    TLDR New treatments for hair loss show promise, especially finasteride for men and a stronger minoxidil formula.
    In 1998, the treatment options for androgenetic alopecia (AGA) were enhanced with the U.S. approval of Propecia (finasteride) and Rogaine Extra Strength 5% (minoxidil). The paper reviewed these new products, other promising compounds in clinical trials, and over-the-counter treatments, while discussing the biological pathways involved in AGA. Finasteride, which inhibits the conversion of testosterone to DHT, was approved for use in men and showed effectiveness in increasing hair count and patient satisfaction, although its effects in women were still under investigation. Minoxidil had been in use for over a decade, with the new 5% version showing modest hair growth improvements. Other compounds like GI198745 and lamin (prezatide copper), as well as over-the-counter remedies, were also explored, but their efficacy was less certain. The paper stressed the importance of managing patient expectations and providing information on the efficacy and testing status of alopecia treatments.
    Discuss this study in the Community →

    Research cited in this study

    6 / 6 results

    Related Community Posts Join

    6 / 1000+ results

      community 1 month of using fin, so happy

      in Progress Pictures  865 upvotes 6 months ago
      User had a hair transplant and used a finasteride and minoxidil spray for 6 months with no results. After adding finasteride tablets for 1 month, they saw significant hair growth improvement.

      community 19 yo destroyed hairline even though using Fin/min/microneedling for 16months/11months/3months … Idk what to do.

      in Progress Pictures  260 upvotes 1 year ago
      A 19-year-old has been using finasteride, minoxidil, and microneedling to treat hair loss with no regrowth, feeling mentally affected by it. Advice given includes continuing treatment, considering a hair transplant, addressing potential vitamin deficiencies, and possibly switching to dutasteride or adding ketoconazole shampoo.

      community Haircafe on why microneedling is bad for hair growth

      in Microneedling  158 upvotes 6 months ago
      Microneedling combined with minoxidil and finasteride shows significant hair regrowth, though opinions on its effectiveness vary. Some users report substantial benefits, while others highlight the need for more research and consistency in application.

      community Why nobody uses 0.25% (2.5mg/ml)?

      in Treatment  66 upvotes 1 year ago
      The conversation is about the effectiveness of 0.25% topical finasteride compared to other concentrations and forms. Users discuss its potential for better scalp DHT reduction and fewer side effects, with some preferring topical over oral treatments.

      community Scientific evidence for Peppermint & Rosemary oils + My Experience

      in Research/Science  114 upvotes 2 years ago
      Natural treatments for hair loss, specifically peppermint oil and rosemary oil; how they can be used as a supplementary or alternative treatment to pharmaceuticals such as finasteride and minoxidil; and the personal experience of the user Divallo, who has seen an increase in density and thickness after using these oils for around 2.5 years. The post also touches on the potential antifungal properties of the oils and their effects on cutaneous blood flow.

    Related Research

    4 / 4 results