Baricitinib Results in Eyebrow and Eyelash Growth in Patients With Alopecia Areata Who Do Not Achieve 20% or Less Scalp Hair Loss

    September 2022 in “ Journal of The American Academy of Dermatology ”
    Maryanne M. Senna, Oh Sang Kwon, Bianca Maria Piraccini, Rodney Sinclair, Susan Ball, Yuxin Ding, Yunfei Chen, Yves Dutronc, Brett King
    Image of study
    TLDR Baricitinib helps grow eyebrows and eyelashes in severe alopecia areata patients.
    The document presents an analysis of two randomized, double-blinded, placebo-controlled trials (BRAVE-AA1 and BRAVE-AA2) evaluating the efficacy of Baricitinib, an oral selective Janus kinase (JAK)1/JAK2 inhibitor, in promoting eyebrow and eyelash regrowth in patients with severe alopecia areata (AA) who did not achieve a Severity of Alopecia Tool (SALT) score ≤20 (20% or less scalp hair loss) at Week 36. The results showed that in patients with a SALT score >20 at Week 36, treatment with baricitinib 4 mg resulted in achievement rates of 19.8% for ClinRo EB (0, 1) and 22.6% for ClinRo EL (0, 1) versus 3.5-3.9% with placebo (P ≤ .001). For baricitinib 2 mg, the rate of ClinRo EB (0, 1) was 10.4% (P ≤ .01 versus placebo 3.5%) and ClinRo EL was 9.4% (P = .051, versus placebo 3.9%). Therefore, baricitinib therapy resulted in clinically meaningful improvement in hair growth for eyebrows and eyelashes in those with SALT score >20 at Week 36.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 11 results

      community What else is good. Besides the big 3.

      in Chat  34 upvotes 2 months ago
      Key treatments for hair preservation include minoxidil, finasteride/dutasteride, and microneedling, with additional options like specific shampoos, oils, biotin, zinc, tretinoin, clascoterone, and low-level laser therapy. Maintaining a healthy lifestyle, reducing stress, and addressing nutrient deficiencies can also support hair health.

      community I am a dermatologist with a clinical interest in alopecia. AMA

      in Will treatment work for me? 2 years ago
      In this conversation, 4990 discussed various treatments for hair loss, including oral minoxidil, PRP, transplan, Jak inhibitors, Dutasteride, Finasteride, Olumiant, Ketoconazole, RU58841, microneedling, baricitinib, and CCCA. They recommended scalp biopsies in unclear cases of DUPA, twice weekly to twice daily shampooing for topical minoxidil users, and two sessions spaced one month apart with follow up at month three to determine the effectiveness of PRP treatment.

      community Olumiant active ingredient Baricitinib

      in Research/Science  1 upvotes 2 years ago
      The conversation is about someone inquiring if anyone has tried Olumiant or its active ingredient, Baricitinib, for hair loss, mentioning the cost and that they have ordered Baricitinib.

    Related Research

    6 / 6 results