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GlossaryJanus Kinase 2 (JAK2)

enzyme involved in cell signaling and blood cell production

Janus Kinase 2 (JAK2) is an enzyme that plays a crucial role in the signaling pathways of various types of cells, including those involved in the immune system and blood cell production. Mutations in the JAK2 gene are often associated with certain blood disorders and cancers, such as polycythemia vera and essential thrombocythemia, making it a significant target for medical research and treatment development.

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research Epigallocatechin-3 Gallate Inhibits STAT-1/JAK2/IRF-1/HLA-DR/HLA-B and Reduces CD8 NKG2D Lymphocytes in Alopecia Areata Patients

15 citations, December 2018 in “International journal of environmental research and public health/International journal of environmental research and public health”

EGCG may help treat alopecia areata by blocking certain immune responses and reducing specific harmful immune cells.

research Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms

52 citations, September 2018 in “International Journal of Molecular Sciences”

Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.

research Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata

42 citations, April 2021 in “JCI insight”

Blocking JAK3 signaling can reverse hair loss from alopecia areata.

research Two Cases of Alopecia Areata Treated with Ruxolitinib: A Discussion of Ideal Dosing and Laboratory Monitoring

25 citations, March 2017 in “International Journal of Dermatology”

Ruxolitinib effectively and safely regrows hair in alopecia patients.

research Interleukin-6 Null Mice Paradoxically Display Increased STAT3 Activity and Wound-Induced Hair Neogenesis

16 citations, January 2016 in “Journal of Investigative Dermatology”

Mice without the IL-6 gene had more hair growth after injury due to higher activity of a related protein, Stat3.

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community The "DHT" itch myth - it's more complicated

in Product 6 upvotes 1 year ago

A user found that scalp itch might be linked to inflammation rather than DHT alone and noticed hair improvement with certain cancer drugs. They also discovered that black seed oil relieved their scalp itch and are experimenting with a mix of essential oils for dry scalp, questioning if oils affect minoxidil absorption.