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GlossaryJanus Kinase 1 (JAK1)

enzyme involved in immune signaling and cell growth

Janus Kinase 1 (JAK1) is an enzyme that plays a crucial role in the signaling pathways of various cytokines, which are proteins important for immune system communication. It is part of the JAK family of tyrosine kinases and is involved in processes such as cell growth, development, and immune responses. In the context of hair and alopecia, JAK1 inhibitors are being researched as potential treatments for conditions like alopecia areata, an autoimmune disorder that causes hair loss.

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research Selective Inhibition of JAK3 Signaling Is Sufficient to Reverse Alopecia Areata

42 citations , April 2021 in “JCI insight”

Blocking JAK3 signaling can reverse hair loss from alopecia areata.

research Efficacy of Baricitinib in Patients With Different Degrees of Severe Alopecia Areata: 52-Week Results From BRAVE-AA1 and BRAVE-AA2

June 2023 in “British Journal of Dermatology”

Baricitinib was effective in treating severe and very severe alopecia areata after 52 weeks.

research Baricitinib Results in Eyebrow and Eyelash Growth in Patients With Alopecia Areata Who Do Not Achieve 20% or Less Scalp Hair Loss

1 citations , September 2022 in “Journal of The American Academy of Dermatology”

Baricitinib helps grow eyebrows and eyelashes in severe alopecia areata patients.

Clinician and Patient Evaluation of Improvement for Eyebrow and Eyelashes Hair Loss During Baricitinib Phase 3 Trials BRAVE-AA1 and BRAVE-AA2

research Clinician and Patient Evaluation of Improvement for Eyebrow and Eyelashes Hair Loss During Baricitinib Phase 3 Trials BRAVE-AA1 and BRAVE-AA2

September 2022 in “Journal of The American Academy of Dermatology”

Baricitinib was effective in regrowing eyebrow and eyelash hair in patients with severe alopecia areata.

research Selectively Targeting JAK1 or JAK3 Pathway Is Sufficient to Reverse Alopecia Areata

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking JAK1 or JAK3 helps reverse hair loss in a mouse model of alopecia areata.

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