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GlossaryJanus Kinase 1 (JAK1)

enzyme involved in immune signaling and cell growth

Janus Kinase 1 (JAK1) is an enzyme that plays a crucial role in the signaling pathways of various cytokines, which are proteins important for immune system communication. It is part of the JAK family of tyrosine kinases and is involved in processes such as cell growth, development, and immune responses. In the context of hair and alopecia, JAK1 inhibitors are being researched as potential treatments for conditions like alopecia areata, an autoimmune disorder that causes hair loss.

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research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations, February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

research Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata

13 citations, September 2022 in “Frontiers in immunology”

Ifidancitinib, a JAK inhibitor, effectively regrows hair in mice with alopecia by tiring out harmful T cells.

research Selectively Targeting JAK1 or JAK3 Pathway Is Sufficient to Reverse Alopecia Areata

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking JAK1 or JAK3 helps reverse hair loss in a mouse model of alopecia areata.

research Oral Ruxolitinib Induces Hair Regrowth in Patients with Moderate-to-Severe Alopecia Areata

196 citations, September 2016 in “JCI insight”

Ruxolitinib effectively regrows hair in most patients with severe hair loss.

research Novel TMEM173 Mutation and the Role of Disease-Modifying Alleles

47 citations, December 2019 in “Frontiers in immunology”

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

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