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GlossaryJanus Kinase 1 (JAK1)

enzyme involved in immune signaling and cell growth

Janus Kinase 1 (JAK1) is an enzyme that plays a crucial role in the signaling pathways of various cytokines, which are proteins important for immune system communication. It is part of the JAK family of tyrosine kinases and is involved in processes such as cell growth, development, and immune responses. In the context of hair and alopecia, JAK1 inhibitors are being researched as potential treatments for conditions like alopecia areata, an autoimmune disorder that causes hair loss.

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research Reversal of Alopecia Areata Following Treatment With the JAK1/2 Inhibitor Baricitinib

184 citations , February 2015 in “EBioMedicine”

A patient with Alopecia Areata had complete hair regrowth after using the drug baricitinib.

research Induction of T Cell Exhaustion by JAK1/3 Inhibition in the Treatment of Alopecia Areata

13 citations , September 2022 in “Frontiers in immunology”

Ifidancitinib, a JAK inhibitor, effectively regrows hair in mice with alopecia by tiring out harmful T cells.

research Alopecia Areata Lesions Show Significant Changes In Immune And Keratin Biomarkers That Correlate With Clinical Improvement With Oral Janus Kinase Inhibitors PF-06651600 (JAK3) And PF-06700841 (TYK2/JAK1)

5 citations , April 2019 in “Journal of Investigative Dermatology”

Oral JAK inhibitors improved alopecia areata by modulating immune responses and boosting hair growth.

research CS12192 Reverses Alopecia Areata by Selectively Targeting JAK3/JAK1/TBK1

February 2025 in “PubMed”

CS12192 effectively treats alopecia areata with better safety than current options.

research Selectively Targeting JAK1 or JAK3 Pathway Is Sufficient to Reverse Alopecia Areata

April 2019 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking JAK1 or JAK3 helps reverse hair loss in a mouse model of alopecia areata.

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