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Glossary Testosterone Production

process by which the body generates the hormone testosterone

Testosterone production, also known as testosterone synthesis or androgen production, refers to the process by which the body generates testosterone, a key male sex hormone. This process primarily occurs in the testes in men and in smaller amounts in the ovaries in women and the adrenal glands in both sexes. Testosterone plays a crucial role in the development of male reproductive tissues, the maintenance of muscle mass, bone density, and the regulation of libido. The production is regulated by the hypothalamus and pituitary gland through a feedback loop involving luteinizing hormone (LH).

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Research

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research Central 5-alpha reduction of testosterone is required for testosterone's inhibition of the hypothalamo-pituitary–adrenal axis response to restraint stress in adult male rats

51 citations , July 2013 in “Brain Research”

Testosterone needs to be converted to DHT to reduce stress response in male rats.

Oral Testosterone in Oil: Pharmacokinetic Effects of 5α-Reduction by Finasteride or Dutasteride and Food Intake in Men

research Oral Testosterone in Oil: Pharmacokinetic Effects of 5 Reduction by Finasteride or Dutasteride and Food Intake in Men

22 citations , January 2006 in “International Journal of Andrology”

This study found that coadministration of 5α-reductase inhibitors with oral testosterone in oil significantly increases serum testosterone levels in medically castrated men compared to testosterone alone, with food intake minimally affecting these levels.

Effects of the Anti-Androgen Finasteride on 5α-Reduction of Androgens in the Presence of Progesterone in Human Gingival Fibroblasts: Modulatory Actions of the Alkaline Phosphatase Inhibitor Levamisole

research Effects of the anti-androgen finasteride on 5α-reduction of androgens in the presence of progesterone in human gingival fibroblasts: modulatory actions of the alkaline phosphatase inhibitor levamisole

9 citations , August 2000 in “Journal of Periodontal Research”

Finasteride reduces testosterone conversion, progesterone lessens this, and levamisole enhances finasteride's effect.

research Potential adverse effects of long-term testosterone therapy

72 citations , October 1998 in “Baillière's clinical endocrinology and metabolism”

This article discusses the potential effects of exogenous testosterone, highlighting that its impact on prostate cancer progression, cardiovascular health, and behavior remains uncertain and needs further investigation.

research Hair removal in hirsute women with normal testosterone levels: a randomized controlled trial of long-pulsed diode laser vs. intense pulsed light

41 citations , September 2010 in “British journal of dermatology/British journal of dermatology, Supplement”

In this study, hirsute women with normal or medically normalized testosterone levels experienced similar, though declining, hair reduction from both intense pulsed light and long-pulsed diode laser treatments over six months.

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Community Join

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community Too much testosterone.

6 years ago

The conversation discusses the idea of naturally lowering testosterone levels to potentially reduce DHT and help with hair loss, though it is speculative and not tested by the original poster. Participants suggest using treatments like finasteride, dutasteride, or RU58841 instead, as they directly target DHT without reducing testosterone.

community Why does finasteride increase sexual desire in some users while significantly reducing it in others?

27 upvotes 1 week ago

Finasteride affects libido differently in individuals due to hormonal changes, increasing testosterone and potentially estrogen, which can either boost or reduce sexual desire. Other treatments mentioned include dutasteride and topical applications, with some users experiencing increased libido and others experiencing a decrease.

community Saw palmetto, Alpecin, hormone levels, regrowth. Thought you guys might be interested.

4 upvotes 12 years ago

A person experienced hair regrowth after reducing testosterone levels and using saw palmetto tincture and Alpecin shampoo. Other users suggested treatments like Nizoral shampoo, Aldactone, and supplements for hair loss.

community Is this broscience? From More Plates, More Dates

in Research/Science 21 upvotes 2 years ago

The conversation discusses whether finasteride's reduction of DHT and increase in scalp testosterone contribute to hair follicle miniaturization. Some participants argue testosterone does not cause miniaturization, while others suggest that even with reduced DHT, other androgens like testosterone may still contribute to hair loss.

community Anyone know by what percentage Pyrilutamide or Ru decrease your androgens?

in Chat 1 upvotes 1 year ago

Pyrilutamide and RU58841 are androgen receptor antagonists that block receptors without significantly reducing testosterone or DHT levels. Any indirect effect on androgen levels is likely negligible.

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Learn

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learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Bicalutamide

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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Shreeji Cosmodent Dental Implant & Laser Hair ReductionAhmedabad, Gujarat · IN

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