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Glossary Androgen Hypersecretion

excessive production of male sex hormones by endocrine glands

Androgen hypersecretion refers to the excessive production of androgens, which are male sex hormones like testosterone, by the body's endocrine system. This condition can lead to symptoms such as excessive hair growth (hirsutism), acne, and in severe cases, conditions like polycystic ovary syndrome (PCOS) in women. It can be caused by various factors, including adrenal gland disorders or tumors.

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Research

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research Hyposecretion of the adrenal androgen dehydroepiandrosterone sulfate (DHEA-S) in the majority of the alopecia areata patients: Is it a primitive and pathogenic perturbation of hypothalamic-pituitary-adrenal axis?

3 citations , January 2011 in “International journal of trichology”

Low DHEA-S levels might be linked to alopecia areata and could be a potential treatment target.

Androgens and Erythropoiesis: Induction of Erythropoietin-Hypersecretory State and Effect of Finasteride on Erythropoietin Secretion

research Androgens and erythropoiesis. Induction of erythropoietin-hypersecretory state and effect of finasteride on erythropoietin secretion

10 citations , March 1999 in “Comparative Haematology International”

This study found that chronic administration of testosterone in mice induced an elevated EPO secretion response, possibly mediated through DHT, without affecting baseline EPO levels.

Activation of Nuclear Factor κB in Response to Cream Ingestion Is Related to Ovarian Androgen Hypersecretion in Polycystic Ovary Syndrome

research Activation of nuclear factor κB in response to cream ingestion is related to ovarian androgen hypersecretion in polycystic ovary syndrome

6 citations , August 2013 in “Fertility and Sterility”

This study found that cream ingestion increased NFκB activation in women with PCOS, which was associated with insulin resistance and higher ovarian androgen levels, regardless of obesity status.

Androgenic Alopecia in Females: Diagnosis and Treatment

research Androgenic Alopecia

14 citations , July 1987 in “Dermatologic Clinics”

This article reviews current evaluation and treatment options for androgenic alopecia in women and reports no new clinical results.

research Case Report: A Virilizing Adrenal Oncocytoma

6 citations , March 2021 in “Frontiers in surgery”

This case report describes a 64-year-old woman with hirsutism who was found to have a borderline adrenocortical oncocytoma, successfully treated with adrenalectomy.

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Community Join

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community Androgen degraders for hair loss

61 upvotes 2 years ago

The conversation discusses androgen receptor degraders for hair loss, highlighting their potential advantages over traditional AR blockers like RU58841 and pyrilutamide. Concerns about the safety and cost of these treatments are also mentioned.

community Anti-androgen use causing testicular pain?

in Finasteride/Dutasteride 5 upvotes 1 year ago

Switching from topical finasteride to oral Dutasteride and using Fluridil caused persistent testicular discomfort. The discomfort did not subside after stopping Fluridil, raising concerns about Dutasteride's role.

community anti-androgens help with chronic seborric dermatitis ?! and hence diffuse thinning

7 upvotes 1 year ago

An 18-year-old experiencing hair loss and seborrheic dermatitis has tried finasteride, dutasteride, and various shampoos without success. They are considering anti-androgens like RU58841 and KX-826 for oil control and dandruff reduction.

community Having androgen receptor density and sensitivity at wrong f*ing place

in Satire 7 upvotes 1 year ago

The conversation discusses hair loss treatments, focusing on the use of topical minoxidil, microneedling, finasteride, and dutasteride, while debating the role of testosterone and DHT in hair loss. It also touches on the potential liver health impacts of these treatments and the genetic sensitivity of hair follicles to androgens.

community Anti androgen shed all over scalp

3 upvotes 2 years ago

The user is experiencing intense hair shedding all over the scalp after applying pyrilutamide to the hairline and taking oral castor oil. They are also using topical finasteride and latanoprost, but are unsure which treatment is causing the shedding.

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Learn

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learn Spironolactone

Who can safely use spironolactone for hair thinning and androgen-related hair loss? Women with androgen-related hair loss can safely use spironolactone under medical supervision.

learn GT20029

What is GT20029 and how does it work as a topical anti-androgen for hair loss? GT20029 is a topical anti-androgen that degrades androgen receptors to combat hair loss.

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