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Glossary Testosterone Production

process by which the body generates the hormone testosterone

Testosterone production, also known as testosterone synthesis or androgen production, refers to the process by which the body generates testosterone, a key male sex hormone. This process primarily occurs in the testes in men and in smaller amounts in the ovaries in women and the adrenal glands in both sexes. Testosterone plays a crucial role in the development of male reproductive tissues, the maintenance of muscle mass, bone density, and the regulation of libido. The production is regulated by the hypothalamus and pituitary gland through a feedback loop involving luteinizing hormone (LH).

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Research

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Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial

research Re: Effect of Testosterone Supplementation With and Without a Dual 5α-Reductase Inhibitor on Fat-Free Mass in Men with Suppressed Testosterone Production: A Randomized Controlled Trial

July 2012 in “The Journal of Urology”

This abstract reviews testosterone supplementation with and without a dual 5α-reductase inhibitor on fat-free mass in men with suppressed testosterone production and reports no new research findings.

Production Rates of Testosterone and Dihydrotestosterone in Female Pattern Hair Loss

research Production rates of testosterone and of dihydrotestosterone in female pattern hair loss

17 citations , July 2003 in “Metabolism-clinical and Experimental”

This study found that young women with female-pattern hair loss exhibit increased testosterone production rates while dihydrotestosterone production rates remain within or below the normal range.

research Testosterone alters iron metabolism and stimulates red blood cell production independently of dihydrotestosterone

53 citations , July 2014 in “American Journal of Physiology-Endocrinology and Metabolism”

This study found that testosterone-enanthate increased red blood cell production and altered iron homeostasis in older hypogonadal men without being affected by finasteride, indicating these effects do not require type II 5α-reductase enzyme activity.

research Testosterone and dihydrotestosterone production in genetically furless and furred male rabbits and effects on growth.

1 citations , January 2008 in “Proceedings of the 9th World Rabbit Congress, Verona, Italy, 10-13 June 2008”

This study found that androgenic hormone levels did not explain growth differences between furless and furred male rabbits, despite a potential growth advantage in furless rabbits.

research Obstructive Sleep Apnea Due to Endogenous Testosterone Production in a Woman

66 citations , March 1998 in “Mayo Clinic Proceedings”

This case report describes a 70-year-old woman whose obstructive sleep apnea resolved after the removal of a testosterone-producing ovarian tumor, supporting the theory that testosterone influences OSA in women.

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Community Join

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community Detransitioning, questions about hair loss prevention while body ramps back up testosterone production

in Transgender 2 upvotes 4 months ago

The conversation discusses preventing hair loss during detransitioning, with suggestions to use finasteride or dutasteride as DHT blockers. The user is also considering rosemary oil and monitoring testosterone levels.

community Breezula / pyrilutamide vs topical fin / dut for added protection on TRT?

2 upvotes 4 months ago

A 35-year-old is considering Breezula, Pyrilutamide, or topical finasteride/dutasteride to protect against hair loss while on testosterone replacement therapy (TRT). They currently use finasteride, oral minoxidil, and dutasteride but experienced increased hair shedding with TRT.

community Should I avoid a testosterone cycle if I care a lot about keeping my hair?

in Treatment 5 upvotes 4 weeks ago

Avoid testosterone cycles if you care about hair preservation, as they can accelerate hair loss despite using finasteride. Consider alternatives like dutasteride for better protection against hair loss.

community Hypothetically, if estradiol has been a "cure" for hair loss, could one apply estradiol topically and just take an estrogen blocker and/or testosterone to offset the systematic effects?

8 upvotes 1 year ago

Topical estradiol may help with hair loss but can have systemic effects, like reduced testosterone production. Using estrogen blockers can have negative side effects, such as joint pain and reduced sex drive.

community 3 month progress. Stack: 2.5mg dutasteride, 10mg oral minoxidil, RU58841, and low TRT dosing producing hypogonadism.

73 upvotes 3 months ago

The conversation discusses a hair loss treatment regimen involving 2.5mg dutasteride, 10mg oral minoxidil, RU58841, and low-dose testosterone replacement therapy (TRT). The user reports progress without significant side effects, except for facial bloating from minoxidil.

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Learn

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learn Spironolactone

powerful topical and oral anti-androgen used mostly by women

learn Finasteride

Frontline, gold standard treatment for combatting androgenic alopecia

learn Dutasteride

Heavy duty finasteride that comes with higher risks

learn Saw Palmetto

a natural and far less effective alternative to Finasteride

learn Osteopontin

signaling protein that, when suppressed, may grow hair by reducing inflammation and stem cell loss

learn Bicalutamide

Could bicalutamide help trans women regrow hair lost to testosterone? No study has tested bicalutamide for hair regrowth in trans women. In cisgender women the only randomized trial found it added nothing to minoxidil, and it is an off-label prescription drug that requires liver monitoring.

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