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    Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

    February 1997 in “ Bioorganic & Medicinal Chemistry ”
    Mettilda Lourdusamy, James E. Côté, Sylvie Laplante … S. M. Singh
    Studysummary This study found that among 17 beta-(N-ureylene-N,N'-disubstituted)-4-azasteroids, those with an N'-phenyl moiety were the most effective inhibitors of human type I 5 alpha-reductase.
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    Research cited in this study 8

    1. Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP-Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor Journal of the American Chemical Society · 1996
    2. The Enzyme and Inhibitors of 4-Ene-3-Oxosteroid 5α-Oxidoreductase Steroids · 1995
    3. Synthesis and In Vitro Evaluation of 4-Substituted N-(1,1-Dimethylethyl)-3-Oxo-4-Androstene-17β-Carboxamides as 5α-Reductase Inhibitors and Antiandrogens Journal of Medicinal Chemistry · 1995
    4. Chemical Mechanism of the Covalent Modification of 5-Alpha-Reductases by Finasteride as Probed by Secondary Tritium Isotope Effects Journal of the American Chemical Society · 1995
    5. Finasteride Drugs · 1993
    6. LY191704: A Selective, Nonsteroidal Inhibitor of Human Steroid 5 Alpha-Reductase Type 1 Proceedings of the National Academy of Sciences of the United States of America · 1993
    7. Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase Journal of Medicinal Chemistry · 1993
    8. Structure of Human Type II 5 Alpha-Reductase Gene Endocrinology · 1992