Establishment of Type II 5α-Reductase Over-Expressing Cell Line as an Inhibitor Screening Model

    June 2007 in “ Journal of steroid biochemistry and molecular biology/˜The œJournal of steroid biochemistry and molecular biology ”
    Sunhyae Jang, Young Lee, Seong-Lok Hwang … Chang Deok Kim
    Studysummary This study developed a reliable and convenient cell-based model to screen for type II 5α-reductase inhibitors, identifying Curcumae longae and Mori ramulus extracts as potential candidates.
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    Research cited in this study 6

    1. Androgens and Alopecia Molecular and Cellular Endocrinology · 2002
    2. The Hair Growth Promoting Effect of Sophora Flavescens Extract and Its Molecular Regulation Journal of Dermatological Science · 2002
    3. The Biology of Hair Follicles The New England Journal of Medicine · 1999
    4. Finasteride Is the Main Inhibitor of 5α-Reductase Activity in Microdissected Dermal Papillae of Human Hair Follicles Archives of Dermatological Research · 1999
    5. Comparison of Finasteride, a 5α Reductase Inhibitor, and Various Commercial Plant Extracts in In Vitro and In Vivo 5α Reductase Inhibition The Prostate · 1993
    6. The Secret Life of the Hair Follicle Trends in genetics · 1992

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