A Review on Finasteride: A 5-Alpha Reductase Inhibitor, Its Mechanism, Facts, and Benefits

    June 2019 in “ Journal of Drug Delivery and Therapeutics ”
    Shraddha T. Nemane, Omprakash G. Bhusnure, Sachin B. Gholve, Pooja R. Mitakari, Pawan N. Karwa
    TLDR Finasteride effectively treats hair loss and prostate issues with minimal side effects.
    The review discussed finasteride, a 5-alpha reductase inhibitor, primarily used to treat benign prostatic hyperplasia (BPH) and male androgenetic alopecia. It highlighted that finasteride works by blocking the conversion of testosterone to dihydrotestosterone (DHT), which is responsible for male pattern hair loss. While there were concerns about potential male sexual dysfunction due to its effects on testosterone and DHT, some studies reported insignificant or acceptable adverse effects that diminished over time, suggesting that discontinuation of finasteride was often unnecessary.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 1000+ results

      community Androgenetic alopecia is a skin disease: DHT-mediated skin disorders

      in Research/Science  63 upvotes 2 years ago
      Dihydrotestosterone (DHT) impacts various skin conditions, including Androgenetic alopecia and seborrheic dermatitis, by causing overactivity in sebaceous glands. Topical medications Tacrolimus and Clobetasol can reduce these inflammatory conditions, and treatments like RU58841, Minoxidil, and Finasteride may also be beneficial.

      community Alternatives/unorthodox hairloss protocols to the big three

      in Chat  1 upvotes 2 months ago
      The conversation discusses alternative and unorthodox hair loss treatments, including RU58841, nandrolone, and dianabol, as well as theoretical approaches involving high doses of estrogen and selective estrogen receptor modulators. These methods are considered extreme and potentially harmful but are explored for those unable to tolerate traditional 5-alpha reductase inhibitors.

      community Does Creatine Cause Hair Loss? I Did the Science.

      in Chat  7 upvotes 1 year ago
      Creatine at 2.5 g/day did not affect DHT levels in the user, suggesting it may not cause hair loss through DHT. The user used minoxidil during the experiment but did not use finasteride or other DHT-reducing medications.

    Related Research

    13 / 13 results