Finasteride Treatment and Neuroactive Steroid Formation

    January 2009 in “ PubMed ”
    Marketa Duskova, Martin Hill, M. Hanus … Luboslav Stárka
    Studysummary This study found that finasteride treatment in men with benign prostate hyperplasia significantly altered steroid hormone profiles and may contribute to depressive symptoms by affecting neuroactive steroid levels.
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    Research cited in this study 10

    1. GABAergic Neurosteroids Mediate the Effects of Ethanol on Long-Term Potentiation in Rat Hippocampal Slices European Journal of Neuroscience · 2007
    2. Inhibition of Progesterone Metabolism Mimics the Effect of Progesterone Withdrawal on Forced Swim Test Immobility Pharmacology Biochemistry and Behavior · 2007
    3. The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride Pharmacology, Biochemistry and Behavior · 2006
    4. Finasteride Induced Depression: A Prospective Study BMC clinical pharmacology · 2006
    5. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    6. Depression Related to Finasteride Administration for Androgenetic Alopecia Journal of Dermatology · 2002
    7. Changes in Progesterone Metabolites in the Hippocampus Can Modulate Open Field and Forced Swim Test Behavior of Proestrous Rats Hormones and Behavior · 2002
    8. Clinical and Endocrine Effects of Finasteride, a 5α-Reductase Inhibitor, in Women with Idiopathic Hirsutism Fertility and Sterility · 1995
    9. Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats Progress in Neuro-psychopharmacology & Biological Psychiatry · 1993
    10. C19 and C21 5β/5α Metabolite Ratios in Subjects Treated with the 5α-Reductase Inhibitor Finasteride: Comparison of Male Pseudohermaphrodites with Inherited 5α-Reductase Deficiency The Journal of Clinical Endocrinology and Metabolism · 1990

    Related research 6

    1. Role of Allopregnanolone Biosynthesis in Acute Stress-Induced Anxiety-Like Behaviors in Mice Synapse · 2017
    2. Finasteride Treatment and Neuroactive Steroid Formation PubMed · 2009
    3. Chronic Progesterone Treatment Augments While Dehydroepiandrosterone Sulphate Prevents Tolerance to Ethanol Anxiolysis and Withdrawal Anxiety in Rats European Journal of Pharmacology · 2007
    4. The Anxiolytic Effect of Pregnancy in Rats Is Reversed by Finasteride Pharmacology, Biochemistry and Behavior · 2006
    5. A New Look at the 5-Alpha-Reductase Inhibitor Finasteride Cns Drug Reviews · 2006
    6. A New Look at the 5α-Reductase Inhibitor Finasteride 2006