Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

November 1993 in “ Progress in Neuro-psychopharmacology & Biological Psychiatry ”

Edwin D. Lephart, Douglas A. Husmann

finasteride flutamide dihydrotestosterone DHT androgen metabolism testosterone 5α-reduced androgens hypothalamic tissue pituitary tissue CNS development sexual differentiation hormonal milieu Propecia Androcur DHT testosterone central nervous system hormonal environment

TLDR Treatment during development affects hormone balance and sexual behavior in male rats.

The study examined the effects of administering finasteride, flutamide, or dihydrotestosterone (DHT) during different developmental periods on androgen metabolism in hypothalamic and pituitary tissue of juvenile male rats. The results showed that alterations in the enzyme activities that metabolize testosterone during the "critical period" of CNS development could drastically alter the hormonal milieu of the developing fetus that can influence the sexual differentiation of the rodent brain and subsequent sexual behavior. The study suggests that 5α-reduced androgens may be involved in the sexual differentiation of the rodent brain.

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Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

research Altered Brain And Pituitary Androgen Metabolism By Prenatal, Perinatal Or Pre- And Postnatal Finasteride, Flutamide Or Dihydrotestosterone Treatment In Juvenile Male Rats

26 citations , November 1993 in “Progress in Neuro-psychopharmacology & Biological Psychiatry”

Treatment during development affects hormone balance and sexual behavior in male rats.