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Glossary Central Nervous System

brain and spinal cord controlling body's activities and responses

The Central Nervous System (CNS) consists of the brain and spinal cord, serving as the main control center for the body. It processes sensory information, coordinates voluntary and involuntary actions, and is crucial for functions such as thought, emotion, and movement.

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research In vivo evidence for an increase in 5alpha‐reductase activity in the rat central nervous system following morphine exposure

25 citations , September 2005 in “International Journal of Developmental Neuroscience”

This study found that in rats, morphine exposure may increase 5alpha-reductase activity in the CNS, leading to decreased testosterone levels, an effect blocked by finasteride.

research Folliculotropic mycosis fungoides with central nervous system involvement: Demonstration of tumor clonality in intrafollicular T cells using laser capture microdissection

14 citations , February 2003 in “Journal of the American Academy of Dermatology”

This case report describes the first use of laser capture microdissection to confirm that atypical lymphocytes in a folliculotropic mycosis fungoides case involving the central nervous system were part of the same tumor clone.

research Increase in testosterone metabolism in the rat central nervous system by formalin-induced tonic pain

11 citations , October 2002 in “Pharmacology Biochemistry and Behavior”

This study found that formalin-induced pain in rats nearly eliminates testosterone in the brain and spinal cord by likely increasing 5α-reductase activity, but normalizes serum levels after 24 hours.

research Central nervous system involvement in autoimmune polyglandular syndrome

10 citations , April 2003 in “Clinical neurology and neurosurgery”

This case study reports a 33-year-old man with autoimmune thyroiditis and alopecia universalis experiencing reversible CNS demyelination, possibly due to autoimmune activity against CNS antigens.

research Central nervous system demyelination associated with tofacitinib use in alopecia areata: A case report and literature review

May 2026 in “Journal of Neurosciences in Rural Practice”

This case report describes a 23-year-old woman with alopecia areata who developed new central nervous system demyelination after starting tofacitinib therapy; while the drug was associated with this neurological event, causality is not confirmed. The demyelination was reversible upon stopping the medication and administering corticosteroids.

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community After quitting min and fin I asked AI on how fix the mess I am in and it says:

in Technology 1 year ago

Prolonged use of topical minoxidil and finasteride can lead to neuroendocrine and autonomic dysfunction, causing severe sensitivity and side effects. Recovery involves avoiding these treatments, supporting neurosteroid recovery, calming the sympathetic system, and rebuilding scalp health naturally.

community Androsterone as a Neurosteroid Replacement Strategy for 5α-Reductase Inhibitor–Associated Sexual and Affective Dysfunction

in Research/Science 36 upvotes 2 months ago

Androsterone may help with sexual and affective dysfunction from finasteride by replacing disrupted neurosteroids without increasing androgenic side effects. Controlled testing is needed to confirm its effectiveness and safety.

community Creatine increases DHT?!?!

8 upvotes 5 years ago

Creatine may increase DHT, potentially affecting hair loss, but opinions vary. Users discuss using finasteride and alternatives like plant protein to manage hair loss.

community EU Shouldn't Ban Fin & Dut: PFS is NOT REAL.

10 upvotes 1 year ago

Finasteride and Dutasteride do not cause depression or "Post Finasteride Syndrome," with concerns often linked to the nocebo effect and preexisting mental health issues. The EU is unlikely to ban these drugs, but access may become more restricted due to ongoing debates.

community Any success with skipping Finasteride and going straight to Dutasteride daily?

7 upvotes 1 week ago

Some users prefer starting with finasteride due to its shorter half-life and lower DHT inhibition, while others advocate for using dutasteride directly for its higher efficacy. Dutasteride is considered more effective but may have different side effects due to its inability to cross the blood-brain barrier.

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