A New Look at the 5-Alpha-Reductase Inhibitor Finasteride

    March 2006 in “ Cns Drug Reviews
    Deborah A. Finn, Amy S. Beadles-Bohling, Ethan H. Beckley, Matthew M. Ford, Katherine R. Gililland, Rebecca E. Gorin-Meyer, Kristine M. Wiren
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    TLDR Finasteride treats enlarged prostate and hair loss, but may cause side effects in some patients.
    This document from 2006 discusses the use of finasteride, a 5-alpha-reductase inhibitor, in the treatment of benign prostatic hyperplasia and male pattern hair loss. It also explores the impact of finasteride on neuroactive steroid levels and behavior, as well as its potential uses beyond its current clinical applications. The document highlights preclinical research involving animal models of anxiety and depression and clinical investigations with findings relevant to depression, seizure susceptibility, sexual behavior, and alcohol-related behaviors. Finasteride has been useful in the treatment of benign prostatic hyperplasia and androgenetic alopecia, but side effects have been reported in a small percentage of patients.
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