Synthesis of 5,6,6-[2H3]Finasteride and Quantitative Determination of Finasteride in Human Plasma at Picogram Level by an Isotope-Dilution Mass Spectrometric Method

    December 1995 in “ Journal of Chromatography B: Biomedical Sciences and Applications ”
    Antonio Guarna, Giovanna Danza, Giancarlo Bartolucci, A. Marrucci, Dini S, Mario Serio
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    TLDR Accurate method measures finasteride levels in human plasma using gas chromatography-mass spectrometry.
    This 1995 paper describes a sensitive and accurate method for determining finasteride levels in human plasma using gas chromatography-mass spectrometry and a deuterated internal standard. The method was applied to the determination of the pharmacokinetic profile of finasteride in five male volunteers treated with a single oral 5-mg dose of the drug, and the results were in good agreement with previous studies. The method is suitable for routine determination of finasteride at picogram levels.
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