TLDR Reliable method detects finasteride in human plasma at low doses.
This document describes a validated high-performance liquid chromatographic method for detecting finasteride in human plasma at therapeutic doses. The method was found to be reliable and efficient for quantifying finasteride in human plasma at doses down to 5 mg. The authors also discuss the challenges of detecting finasteride using HPLC due to its low UV absorbance and lack of a functional group for derivatization. Overall, the method was found to be practical and highly reliable.
147 citations,
April 1990 in “The Journal of Clinical Endocrinology and Metabolism” Finasteride safely lowers DHT levels without affecting testosterone.
193 citations,
August 1985 in “Endocrinology” Different animals have unique versions of the enzyme that changes testosterone into another hormone, which is important for creating effective treatments for prostate and hair loss conditions.
45 citations,
August 1994 in “Journal of Chromatography B: Biomedical Sciences and Applications” Method detects finasteride in plasma and semen with high sensitivity and accuracy.
4 citations,
March 2019 in “Acta Chromatographica” Two methods can measure finasteride and tamsulosin hydrochloride; HPLC is more advantageous, while TLC offers better separation.
2 citations,
October 2010 in “European Journal of Drug Metabolism and Pharmacokinetics” Researchers developed a quick and sensitive way to measure finasteride in blood using a small sample size.
15 citations,
March 2007 in “Journal of Pharmaceutical and Biomedical Analysis” Method measures finasteride in plasma, suitable for pharmacokinetic studies.
823 citations,
February 1998 in “Analytical Chemistry” Method detects finasteride in plasma at very low concentrations.
18 citations,
June 2010 in “Journal of Chromatography B” New method measures finasteride in blood quickly and accurately.
